Wang Xiao, Man Shoukuo, Zheng Jinwen, An Zesheng
Institute of Nanochemistry and Nanobiology, College of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China.
State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200433, China.
ACS Macro Lett. 2018 Dec 18;7(12):1461-1467. doi: 10.1021/acsmacrolett.8b00839. Epub 2018 Nov 27.
Baylis-Hillman reaction was used to afford a series of four alkyl α-hydroxymethyl acrylates, methyl (MHMA), ethyl (EHMA), isopropyl (iPrHMA), and -butyl (nBHMA) α-hydroxymethyl acrylate, with tunable water solubility. MHMA and EHMA with high water solubility were identified as suitable candidates for aqueous dispersion polymerization-induced self-assembly (PISA). PISA of EHMA and MHMA using poly(ethylene glycol) macromolecular chain transfer agents (PEG-CTA and PEG-CTA) was investigated under either thermal or photoinitiation at 40-70 °C. Photo-PISA at low temperatures provided both morphological transition and PEG-PEHMA block copolymers with narrow molecular weight distributions. iPrHMA with moderate water solubility was used for dispersion-emulsion polymerization with the formation of vesicles being observed.
利用贝利斯-希尔曼反应制备了一系列四种具有可调水溶性的α-羟甲基丙烯酸烷基酯，即α-羟甲基丙烯酸甲酯（MHMA）、α-羟甲基丙烯酸乙酯（EHMA）、α-羟甲基丙烯酸异丙酯（iPrHMA）和α-羟甲基丙烯酸正丁酯（nBHMA）。具有高水溶性的MHMA和EHMA被确定为用于水分散聚合诱导自组装（PISA）的合适候选物。在40-70°C下，使用聚乙二醇大分子链转移剂（PEG-CTA和PEG-CTA）对EHMA和MHMA进行热引发或光引发的PISA研究。低温下的光引发PISA既提供了形态转变，又提供了具有窄分子量分布的PEG-PEHMA嵌段共聚物。具有中等水溶性的iPrHMA用于分散乳液聚合，并观察到囊泡的形成。
