mRNA-1273疫苗接种后慢性炎症性脱髓鞘性多发性神经病
Chronic Inflammatory Demyelinating Polyneuropathy Post-mRNA-1273 Vaccination.
作者信息
Singh Simranjit, Sanna Fnu, Adhikari Ramesh, Akella Ramya, Gangu Karthik
机构信息
Medicine, Division of General Internal Medicine and Geriatrics, Indiana University School of Medicine, Indianapolis, USA.
Hospital Medicine, Franciscan Health, Lafayette, USA.
出版信息
Cureus. 2022 Apr 27;14(4):e24528. doi: 10.7759/cureus.24528. eCollection 2022 Apr.
Abstract
Massive efforts are being made to develop coronavirus disease 2019 (COVID-19) vaccines at an unprecedented rate. The vaccinations' adverse impact profile, on the other hand, has not been well established. Neurological complications are increasingly reported as a result of these vaccines. One such complication identified is immune-mediated inflammatory polyneuropathy, which affects peripheral nerves and neurons. We report a case of chronic inflammatory demyelinating polyneuropathy (CIDP) post-mRNA-1273 (Moderna) COVID-19 vaccine. Recognizing this complication and distinguishing it from Guillain-Barré syndrome enables timely initiation of treatment. Additionally, our report highlights a possible link between vaccination and subsequent development of CIDP, but conclusive evidence of a causal relationship requires more extensive studies.
摘要
目前正在以前所未有的速度大力研发2019冠状病毒病（COVID-19）疫苗。另一方面，这些疫苗的不良反应情况尚未完全明确。越来越多的报告指出这些疫苗会引发神经并发症。其中一种已被确认的并发症是免疫介导的炎性多神经病，它会影响周围神经和神经元。我们报告了1例接种mRNA-1273（Moderna）COVID-19疫苗后发生慢性炎性脱髓鞘性多神经病（CIDP）的病例。认识到这种并发症并将其与吉兰-巴雷综合征区分开来，有助于及时开始治疗。此外，我们的报告强调了接种疫苗与随后发生CIDP之间可能存在的联系，但因果关系的确凿证据还需要更广泛的研究。
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