Hunan Cancer Hospital/the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
Department of Microbiology, School of Basic Medical Science, Central South University, Changsha, Hunan, China.
J Med Virol. 2022 Oct;94(10):4677-4688. doi: 10.1002/jmv.27903. Epub 2022 Jun 9.
Cancer is still ranked as a leading cause of death according to estimates from the World Health Organization (WHO) and the strong link between tumor viruses and human cancers have been proved for almost six decades. Cell-free DNA (cfDNA) has drawn enormous attention for its dynamic, instant, and noninvasive advantages as one popular type of cancer biomarker. cfDNAs are mainly released from apoptotic cells and exosomes released from cancer cells, including those infected with viruses. Although cfDNAs are present at low concentrations in peripheral blood, they can reflect tumor load with high sensitivity. Considering the relevance of the tumor viruses to the associated cancers, cfDNAs derived from viruses may serve as good biomarkers for the early screening, diagnosis, and treatment monitoring. In this review, we summarize the methods and newly developed analytic techniques for the detection of cfDNAs from different body fluids, and discuss the implications of cfDNAs derived from different tumor viruses in the detection and treatment monitoring of virus-associated cancers. A better understanding of cfDNAs derived from tumor viruses may help formulate novel antitumoral strategies to decrease the burden of cancers that attributed to viruses.
根据世界卫生组织（WHO）的估计，癌症仍然是主要死因之一，肿瘤病毒与人类癌症之间的强关联已被证明近六十年。无细胞游离 DNA（cfDNA）因其动态、即时和非侵入性的优势，作为一种流行的癌症生物标志物而备受关注。cfDNA 主要从凋亡细胞和癌细胞释放的外泌体中释放，包括那些被病毒感染的细胞。尽管 cfDNA 在外周血中的浓度较低，但它们可以高度敏感地反映肿瘤负荷。鉴于肿瘤病毒与相关癌症的相关性，源自病毒的 cfDNA 可以作为早期筛查、诊断和治疗监测的良好生物标志物。在这篇综述中，我们总结了从不同体液中检测 cfDNA 的方法和新开发的分析技术，并讨论了源自不同肿瘤病毒的 cfDNA 在病毒相关癌症的检测和治疗监测中的意义。更好地了解源自肿瘤病毒的 cfDNA 可能有助于制定新的抗肿瘤策略，以减轻归因于病毒的癌症负担。
