选择的离子液体（1-乙基-3-甲基咪唑氯盐、1-丁基-3-甲基咪唑氯盐、1-丁基-1-甲基吡咯烷氯盐和正丁基吡啶氯盐）经饮用水给予 Sprague Dawley（Hsd：Sprague Dawley SD）大鼠和 B6C3F1/N 小鼠的毒性研究。
Toxicity studies of select ionic liquids (1-ethyl-3-methylimidazolium chloride, 1-butyl-3-methylimidazolium chloride, 1-butyl-1-methylpyrrolidinium chloride, and n-butylpyridinium chloride) administered in drinking water to Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice.
机构信息
Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
出版信息
Toxic Rep Ser. 2022 May(103). doi: 10.22427/NTP-TOX-103.
Ionic liquids (ILs) are synthetic solvents with applications in a variety of industrial and chemical industries. Human exposure to this diverse chemical class is primarily through dermal or oral routes. Research suggests toxicity may be associated with IL structural characteristics, including the type of cation base or alkyl chain substitutions associated with the cation. To further investigate this hypothesis, the National Toxicology Program (NTP) conducted 3-month toxicity studies in male and female Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice (n = 10/sex/exposure group; 3 exposure concentrations per IL) to compare the relative toxicities of four ILs administered via drinking water-1-ethyl-3-methylimidazolium chloride (Emim-Cl), 1-butyl-3-methylimidazolium chloride (Bmim-Cl), 1-butyl-1-methylpyrrolidinium chloride (Bmpy-Cl), and n-butylpyridinium chloride (NBuPy-Cl). (Abstract Abridged).
离子液体 (ILs) 是一种合成溶剂，在各种工业和化学工业中有应用。人类主要通过皮肤或口服途径接触到这种多样化的化学物质。研究表明，毒性可能与 IL 的结构特征有关，包括与阳离子相关的阳离子碱基或烷基链取代的类型。为了进一步验证这一假设，国家毒理学计划 (NTP) 在雄性和雌性 Sprague Dawley (Hsd:Sprague Dawley SD) 大鼠和 B6C3F1/N 小鼠中进行了为期 3 个月的毒性研究（每组 10 只/性别/暴露组；每组有 3 个暴露浓度)，比较了通过饮用水途径给予的四种 IL 的相对毒性-1-乙基-3-甲基咪唑氯盐（Emim-Cl）、1-丁基-3-甲基咪唑氯盐（Bmim-Cl）、1-丁基-1-甲基吡咯烷氯盐（Bmpy-Cl）和正丁基吡啶氯盐（NBuPy-Cl）。（摘要摘要）。
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