光降解型抗菌剂：合成与降解机制。

Department of Chemistry, Bioscience and Environmental Engineering, Faculty of Science and Technology, University of Stavanger, Stavanger NO-4036, Norway.

Department of Chemistry, University of Bergen, Bergen NO-5007, Norway.

J Org Chem. 2022 Jun 17;87(12):8034-8047. doi: 10.1021/acs.joc.2c00681. Epub 2022 Jun 2.

As a strategy to inactivate antimicrobial agents after use, we designed a range of ethanolamine derivatives where four of them possessed interesting activity. The ethanolamine moiety facilitates photodecomposition, which in a potential drug will take place after use. Herein, the synthetic preparation of these compounds and the mechanism of photoinactivation are described.

作为一种在使用后使抗菌剂失活的策略，我们设计了一系列乙醇胺衍生物，其中有 4 种具有有趣的活性。乙醇胺部分有助于光分解，这在潜在药物中将会在使用后发生。本文描述了这些化合物的合成制备和光灭活机制。