Pesenti Théo, Nicolas Julien
Université Paris-Saclay, CNRS, Institut Galien Paris-Saclay, 92296 Châtenay-Malabry, France.
ACS Macro Lett. 2020 Dec 15;9(12):1812-1835. doi: 10.1021/acsmacrolett.0c00676. Epub 2020 Dec 2.
Radical ring-opening polymerization (rROP) allows facile incorporation of labile groups (e.g., ester) into the main chain of vinyl polymers to obtain (bio)degradable materials. rROP has focused a lot of attention especially since the advent of reversible deactivation radical polymerization (RDRP) techniques and is still incredibly moving forward, as attested by the numerous achievements in terms of monomer synthesis, macromolecular engineering, and potential biomedical applications of the resulting degradable polymers. In the present Viewpoint, we will cover the latest progress made in rROP in the last ∼5 years, such as its recent directions, its remaining limitations, and the ongoing challenges. More specifically, this will be achieved through the three different classes of monomers that recently caught most of the attention: cyclic ketene acetals (CKA), thionolactones, and macrocyclic monomers.
自由基开环聚合（rROP）能够轻松地将不稳定基团（如酯基）引入到乙烯基聚合物的主链中，从而获得（可）生物降解材料。特别是自从可逆失活自由基聚合（RDRP）技术出现以来，rROP受到了广泛关注，并且仍在不断取得令人瞩目的进展，这体现在可降解聚合物在单体合成、大分子工程以及潜在生物医学应用等方面所取得的众多成果上。在本观点文章中，我们将介绍过去约5年里rROP取得的最新进展，例如其近期的发展方向、仍然存在的局限性以及面临的挑战。更具体地说，这将通过最近最受关注的三类不同单体来实现：环状烯酮缩醛（CKA）、硫代内酯和大环单体。
