Clinics of Obstetrics and Gynecology, Ministry of Health, Gaziantep Şehitkamil State Hospital, Gaziantep, Turkey.
Department of Obstetrics and Gynecology, University of Health Sciences, Ankara City Hospital, Ankara, Turkey.
J Obstet Gynaecol. 2022 Oct;42(7):3048-3054. doi: 10.1080/01443615.2022.2081796. Epub 2022 Jun 2.
Advanced glycation end-products (AGE) are complex compounds formed by nonenzymatic glycosylation of proteins, nucleic acids, and lipids with glucose in the blood. We aimed to investigate whether there was a difference in first-trimester serum AGE levels of pregnant women with and without risk factors for gestational diabetes mellitus (GDM) and their obstetric outcomes. There were 44 women in study group who have risk factors for GDM and 44 as controls. Demographic features, serum AGE levels, adverse perinatal and neonatal outcomes were compared between groups. Five patients (11.4%) in the study group and one patient (2.3%) in the control group were diagnosed as GDM ( = .2). The serum AGE values were not statistically different between the study and control groups. There were no statistical differences between groups in terms of adverse perinatal and neonatal outcomes. However, in the group with adverse perinatal outcome ( = 25), AGE values were higher than the control group. The results of our preliminary study suggested that high-risk women for GDM did not have increased serum levels of AGE in the first trimester. Nevertheless, a high first-trimester serum AGE level was found to be associated with adverse perinatal outcomes. IMPACT STATEMENT Advanced glycation end products (AGE) are markers that are associated with diabetes and its complications. For pregnant women, a high third trimester serum AGEs levels were found in women who had gestational diabetes. The results of our study revealed that first trimester screening of serum AGE levels of women who had risk factors for gestational diabetes was not discriminate. Nevertheless, a high first trimester serum AGE levels was associated with adverse perinatal outcome. Whether reducing exogenous sources of AGE (western-style diet, smoking) before pregnancy will be associated with better pregnancy outcomes should be investigated in future studies.
晚期糖基化终产物（AGE）是血液中葡萄糖与蛋白质、核酸和脂质非酶糖化形成的复杂化合物。我们旨在研究患有和不患有妊娠糖尿病（GDM）危险因素的孕妇在妊娠早期血清 AGE 水平是否存在差异及其产科结局。研究组有 44 名有 GDM 危险因素的患者，对照组有 44 名。比较两组间的人口统计学特征、血清 AGE 水平、不良围产儿和新生儿结局。研究组 5 例（11.4%）和对照组 1 例（2.3%）患者被诊断为 GDM（=0.2）。研究组和对照组的血清 AGE 值无统计学差异。两组间不良围产儿和新生儿结局无统计学差异。然而，在不良围产儿结局组（=25），AGE 值高于对照组。我们初步研究的结果表明，GDM 高危妇女在妊娠早期并未出现血清 AGE 水平升高。然而，较高的妊娠早期血清 AGE 水平与不良围产儿结局相关。
备注：本文涉及医学专有名词，因此翻译可能不够准确。
