黏连蛋白RAD21基因启动子甲基化与乳腺癌患者较好的预后相关。
Cohesin RAD21 Gene Promoter Methylation Correlated with Better Prognosis in Breast Cancer Patients.
作者信息
Cui Rongrong, Chen Pu, Wang Yuanyuan, Lu Rong, Ji Meiju, Hou Peng, Qu Yiping
机构信息
Key Laboratory for Tumor Precision Medicine of Shaanxi Province and Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Center for Translational Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
出版信息
Cytogenet Genome Res. 2022;162(3):109-118. doi: 10.1159/000524735. Epub 2022 Jun 2.
RAD21 plays multiple roles in numerous cancers. In breast cancer (BC), a high level of RAD21 correlates with poor disease outcomes and resistance to chemotherapy. However, data regarding RAD21 promoter methylation in BC tissue and its correlation with clinical outcomes in patients with BC remain limited. Here, we investigated the clinicopathological features associated with the methylation status of RAD21 in BC to figure out its possible role in pathogenesis and the formation of breast carcinogenesis. The methylation status of the RAD21 gene was significantly associated with better clinical outcomes in patients with BC.
RAD21在多种癌症中发挥多种作用。在乳腺癌（BC）中，高水平的RAD21与不良疾病预后和化疗耐药相关。然而，关于BC组织中RAD21启动子甲基化及其与BC患者临床结局的相关性的数据仍然有限。在此，我们研究了与BC中RAD21甲基化状态相关的临床病理特征，以弄清楚其在发病机制和乳腺癌发生形成中的可能作用。RAD21基因的甲基化状态与BC患者较好的临床结局显著相关。
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