阿尔茨海默病和代谢性疾病中的认知障碍：儿茶酚胺能假说。
Cognitive Impairment in Alzheimer's and Metabolic Diseases: A Catecholaminergic Hypothesis.
机构信息
Departamento de Ciencias de la Salud, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana (UAM), Unidad Lerma. Av. de las Garzas No. 10, Col. el Panteón, Lerma de Villada, Estado de México, C.P. 52005, Mexico.
División de Neurociencias. Instituto de Fisiología Celular, Universidad Nacional Autónoma de México (UNAM), Circuito Exterior, Ciudad Universitaria, 04510 Mexico City, Mexico.
出版信息
Neuroscience. 2022 Aug 10;497:308-323. doi: 10.1016/j.neuroscience.2022.05.031. Epub 2022 May 30.
Catecholaminergic transmission plays an essential role in both physiological and pathological cognitive functions. Plastic changes subserving learning and memory processes are highly dependent on catecholaminergic activity, altering their function and impacting cognition. This review assesses changes in the dopaminergic and norepinephrine systems as part of the mechanisms underlying cognitive impairment in Alzheimer's disease as associated with metabolic dysfunctions such as type 2 diabetes, metabolic syndrome, and neuroinflammation and peripheral inflammation. Understanding the role of catecholaminergic systems in these conditions is relevant for identifying etiological factors that could advance diagnostic and therapeutic approaches for ameliorating cognitive alterations, disease onset, and progression.
儿茶酚胺能传递在生理和病理认知功能中都起着重要作用。支持学习和记忆过程的可塑性变化高度依赖儿茶酚胺活性，改变其功能并影响认知。本综述评估了多巴胺能和去甲肾上腺素能系统的变化，作为阿尔茨海默病认知障碍相关机制的一部分，这些机制与代谢功能障碍有关，如 2 型糖尿病、代谢综合征、神经炎症和外周炎症。了解儿茶酚胺能系统在这些情况下的作用对于确定可能有助于改善认知改变、疾病发作和进展的病因因素具有重要意义。
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