CCN1 通过淀粉样前体蛋白抑制食管鳞癌细胞增殖，而不涉及 DR6。
CCN1 suppresses cell proliferation of esophageal squamous cell carcinoma through amyloid precursor protein without DR6 participation.
机构信息
Inner Mongolia Institute of Digestive Diseases, Inner Mongolia Engineering Research Center for Prevention and Treatment of Digestive Diseases, The Second Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, 30 Hudemulin Rd, Baotou 014030, China.
Inner Mongolia Institute of Digestive Diseases, Inner Mongolia Engineering Research Center for Prevention and Treatment of Digestive Diseases, The Second Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, 30 Hudemulin Rd, Baotou 014030, China.
出版信息
Cell Signal. 2022 Aug;96:110374. doi: 10.1016/j.cellsig.2022.110374. Epub 2022 May 30.
Esophageal cancer is commonly seen as either squamous cell carcinoma (ESCC) or adenocarcinoma (EAC), two very different cancers. CCN1 is a matricellular protein that induces apoptosis in EAC cells through upregulation of DR5, a death receptor, while its role in ESCC is unclear. DR6 is another death receptor, which has been reported to induce apoptosis, necroptosis, or pyroptosis in various cell systems with or without the engagement of its putative ligand amyloid precursor protein (APP). In this study, we found that CCN1 and DR6 were both highly expressed in ESCC but downregulated in EAC. Overexpression of CCN1 in ESCC cells inhibited cell proliferation through upregulation of APP and its association with p53 without DR6 involvement. Overexpression of APP stopped cell growth, but overexpression of DR6 did not affect cell growth or cell death whatsoever.
食管癌通常表现为鳞状细胞癌（ESCC）或腺癌（EAC），这是两种非常不同的癌症。CCN1 是一种基质细胞蛋白，通过上调死亡受体 DR5 诱导 EAC 细胞凋亡，而其在 ESCC 中的作用尚不清楚。DR6 是另一种死亡受体，已有报道称其在各种细胞系统中诱导凋亡、坏死或焦亡，无论其假定配体淀粉样前体蛋白（APP）是否参与。在这项研究中，我们发现 CCN1 和 DR6 在 ESCC 中均高度表达，而在 EAC 中则下调。CCN1 在 ESCC 细胞中的过表达通过上调 APP 及其与 p53 的结合而不涉及 DR6 来抑制细胞增殖。过表达 APP 停止细胞生长，但过表达 DR6 对细胞生长或细胞死亡没有任何影响。
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