State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Key Laboratory of Biomedical Engineering, Chongqing Medical University, Chongqing, PR China.
Department of Gynecology, Suining Central Hospital, Sichuan, PR China.
Int J Hyperthermia. 2022;39(1):772-779. doi: 10.1080/02656736.2022.2081734.
To investigate the value of the image indexes of B-mode and power Doppler sonography in predicting the therapeutic efficacy of high intensity focused ultrasound (HIFU) ablation for uterine fibroids.
Two hundred and three patients with a solitary uterine fibroid were enrolled in this study. Every patient underwent transvaginal sonography (TVS) and magnetic resonance imaging (MRI) before HIFU. The patients were divided into hypointense, isointense and hyperintense fibroid groups based on T2 weighted MR imaging characteristics, and ultrasonic image indexes of the fibroids in different groups were compared. Multiple linear regression analysis was used to evaluate the correlation between ultrasonic image indexes and energy efficiency factor (EEF), non-perfused volume (NPV) ratio of uterine fibroids.
Among them, 72 patients had a hypointense fibroid, 70 had an isointense fibroid and 61 had a hyperintense fibroid. Significant differences were observed in the ultrasound imaging gray scale value difference between the myometrium and uterine fibroids (GSmyo-fib), the ultrasound imaging gray scale value ratio of fibroids over the myometrium (GSfib/myo), and the ratio of power Doppler pixel area to fibroid area (PDPA/FA) among the three groups ( < 0.05). Linear regression analysis showed that the PDPA/FA and the location of fibroids were the factors affecting the NPV ratio, a model for predicting the NPV ratio was established.
A model with the PDPA/FA for NPV ratio could be used to predict the therapeutic efficacy of HIFU for fibroids.
探讨灰阶超声及能量多普勒超声图像指标在预测高强度聚焦超声（HIFU）消融治疗子宫肌瘤疗效中的价值。
本研究纳入 203 例单发子宫肌瘤患者，所有患者均在 HIFU 治疗前行经阴道超声（TVS）和磁共振成像（MRI）检查。根据 T2WI 成像特征将患者分为低信号、等信号和高信号子宫肌瘤组，比较不同组子宫肌瘤的超声图像指标。采用多元线性回归分析评估超声图像指标与能量效率因子（EEF）、子宫肌瘤无灌注体积（NPV）比值的相关性。
其中低信号子宫肌瘤 72 例，等信号子宫肌瘤 70 例，高信号子宫肌瘤 61 例。三组间子宫肌层与子宫肌瘤超声灰阶差值（GSmyo-fib）、子宫肌瘤超声灰阶值与子宫肌层比值（GSfib/myo）、能量多普勒像素面积与肌瘤面积比值（PDPA/FA）比较，差异均有统计学意义（ < 0.05）。线性回归分析显示，PDPA/FA 及肌瘤位置是影响 NPV 比值的因素，建立了 NPV 比值预测模型。
PDPA/FA 比值预测子宫肌瘤 HIFU 治疗疗效的模型。
