Corey J P, Caldarelli D D, Gould H J
Am J Otol. 1987 Jan;8(1):14-7.
Thirty patients with Crouzon's disease were evaluated longitudinally for type, incidence, and progression of otopathologic changes. The spectrum of otopathologic manifestations included otitis media with effusion, tympanic membrane atelectasis, tympanic membrane perforation, cholesteatoma, and grade I microtia. The frequency of ear disease progressed from 37% during infancy to 62% in older patients. The degree and type of hearing loss were also analyzed. Radiographic cephalometric measurements of the nasopharynx and temporal bone illustrated growth disturbances of the nasopharyngeal dimensions that worsened with increasing age. Our findings suggest that patients with Crouzon's disease are at risk from birth for otitis media with effusion and its sequelae and that the consequent incidence and severity of otopathologic changes increase with age.
对30例克鲁宗病患者的耳部病理变化类型、发生率及进展情况进行了纵向评估。耳部病理表现谱包括中耳积液、鼓膜内陷、鼓膜穿孔、胆脂瘤和I级小耳畸形。耳部疾病的发生率从婴儿期的37%上升至老年患者的62%。还分析了听力损失的程度和类型。鼻咽部和颞骨的放射学头颅测量显示，鼻咽部尺寸的生长紊乱随着年龄增长而加重。我们的研究结果表明，克鲁宗病患者从出生起就有患中耳积液及其后遗症的风险，且随之而来的耳部病理变化的发生率和严重程度会随着年龄增长而增加。
