Jemisingh P, M MaalikBabu A N, Arumugam V, Palanivel Nirmaladevi
Department of Dermatology, Venereology and Leprosy, Tirunelveli Medical College and Hospital (TVMCH), Tirunelveli, Tamil Nadu, India.
Indian J Dermatol. 2022 Jan-Feb;67(1):93. doi: 10.4103/ijd.ijd_271_21.
Anaplastic thyroid carcinoma is a highly aggressive tumor with 100% mortality that constitutes 1%-2% of thyroid malignancies. Cutaneous metastases from thyroid carcinoma are extremely rare. We report a case of a 68-year-old male with anaplastic thyroid carcinoma with cervical lymph node and thoracic cutaneous metastases. Following the diagnosis of anaplastic carcinoma with stage IVB after thorough investigations, he was started on chemotherapy with cisplatin and adriamycin, and also radiotherapy was given subsequently. Dermatological examination showed a single ulcer of size 3 × 2 cm, hard nodules, and plaques of varied sizes present over the anterior chest. Skin biopsy from the nodule showed pleomorphic tumor cells in strands with colloid material and neutrophilic infiltrates in the deep dermis. The present case report demonstrates that thoracic skin metastases can occur from anaplastic thyroid carcinoma with nodules and ulcers and, to our knowledge, this is the first case report of such an extremely rare condition from India.
间变性甲状腺癌是一种侵袭性很强的肿瘤,死亡率达100%,占甲状腺恶性肿瘤的1%-2%。甲状腺癌的皮肤转移极为罕见。我们报告一例68岁男性间变性甲状腺癌患者,伴有颈部淋巴结和胸部皮肤转移。经过全面检查诊断为IVB期间变性癌后,开始给予顺铂和阿霉素化疗,随后进行放疗。皮肤科检查显示前胸有一个3×2厘米的单一溃疡、硬结节以及大小不等的斑块。结节的皮肤活检显示真皮深层有多形性肿瘤细胞条索,伴有胶质物质和嗜中性粒细胞浸润。本病例报告表明,间变性甲状腺癌可发生胸部皮肤转移,出现结节和溃疡,据我们所知,这是印度首例关于这种极其罕见情况的病例报告。