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综合泛癌分析揭示UHRF1介导的DNA甲基化和免疫浸润在肾细胞癌中的作用。

Comprehensive Pan-Cancer Analysis Reveals the Role of UHRF1-Mediated DNA Methylation and Immune Infiltration in Renal Cell Carcinoma.

作者信息

Pan Xiao, Li Caiqin, Cai Yanqun, Wu Susu

机构信息

Taizhou Municipal Hospital, China.

出版信息

J Oncol. 2022 May 23;2022:3842547. doi: 10.1155/2022/3842547. eCollection 2022.

DOI:10.1155/2022/3842547
PMID:35656341
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9152404/
Abstract

Ubiquitin-like PHD and ring finger domain protein 1 (UHRF1) are members of the multifunctional UHRF family, which can participate in DNA methylation change and histone posttranslational change through particular domains and participate in the event and development of tumors. The purpose of this study was to decide the molecular traits and potential medicine-based importance of UHRF1 that helped settle methylated immune infiltration in generalized cancer by carefully studying the relationship between UHRF1 expression and a variety of tumors and to further check for truth the functional role of UHRF1 in kidney-related cancer. A comprehensive analysis of UHRF1 in 33 cancers was performed based on TCGA database. This research involves analysis of mRNA expression profiles, prognostic value, immune infiltration, immune neoantigens, TMB, microsatellite instability, DNA methylation, and gene set enrichment analysis (GSEA). Both immune infiltration and DNA methylation were used to evaluate the importance and method of UHRF1 in renal cancer. The results showed that tumor tissue had higher expression level of UHRF1 than usual tissue. The high expression level of UHRF1 is related to the survival rate of renal cancer. UHRF1 expression was associated with tumor mutation load and microsatellite instability in different cancer types, and enrichment analysis identified terminology and pathways associated with UHRF1. This study showed that UHRF1 plays an important role in the group of objects and development of 33 tumors. UHRF1 may serve as a biomarker of immune infiltration and poor outlook of cancer.

摘要

泛素样植物同源结构域和环指结构域蛋白1（UHRF1）是多功能UHRF家族的成员，其可通过特定结构域参与DNA甲基化改变和组蛋白翻译后修饰，并参与肿瘤的发生发展。本研究旨在通过仔细研究UHRF1表达与多种肿瘤之间的关系，确定UHRF1的分子特征及其潜在的医学重要性，以帮助解决广义癌症中的甲基化免疫浸润问题，并进一步验证UHRF1在肾癌中的功能作用。基于TCGA数据库对33种癌症中的UHRF1进行了综合分析。本研究涉及mRNA表达谱分析、预后价值、免疫浸润、免疫新抗原、肿瘤突变负荷（TMB）、微卫星不稳定性、DNA甲基化和基因集富集分析（GSEA）。同时利用免疫浸润和DNA甲基化来评估UHRF1在肾癌中的重要性和作用方式。结果显示，肿瘤组织中UHRF1的表达水平高于正常组织。UHRF1的高表达水平与肾癌的生存率相关。UHRF1的表达与不同癌症类型中的肿瘤突变负荷和微卫星不稳定性相关，富集分析确定了与UHRF1相关的术语和通路。本研究表明，UHRF1在33种肿瘤的发生发展中起重要作用。UHRF1可能作为免疫浸润和癌症预后不良的生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a99/9152404/43587c82731a/JO2022-3842547.010.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a99/9152404/7d8459777277/JO2022-3842547.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a99/9152404/5373ad0dad06/JO2022-3842547.007.jpg
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