对日本大麦町犬中铜相关肝炎的遗传性进行系谱研究。
Pedigree study of the heredity of copper-associated hepatitis in Dalmatians in Japan.
机构信息
Department of Veterinary Radiology (Nakaichi, Iseri, Horikirizono), Department of Veterinary Small Animal Clinical Science (Itoh, Itamoto), Department of Veterinary Surgery (Sunahara, Nemoto, Tani), Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi 753-8515, Japan.
出版信息
Can Vet J. 2022 Jun;63(6):633-636.
The pedigrees of 3 Dalmatian dogs afflicted with copper-associated hepatitis were investigated to discover the mode of inheritance. A composite family pedigree showed that the 3 affected Dalmatians were related. None of the parents of the affected dogs showed clinical symptoms of liver disease, and the disease had no sex predisposition. The estimated segregation ratio was approximately 3:1 based on surviving littermates. These findings suggested that the copper-associated hepatitis in these Dalmatians was an autosomal recessive mode of inheritance. In addition, some male Dalmatians imported from abroad might have been involved in the occurrence of this disease in Japan.
对 3 只患有铜相关肝炎的大麦町犬的系谱进行了调查，以发现其遗传方式。一个复合家族系谱表明，这 3 只受影响的大麦町犬是有关系的。受影响犬的父母均未表现出肝脏疾病的临床症状，且该病无性别倾向。根据幸存的同窝仔犬，估计分离比约为 3:1。这些发现表明，这些大麦町犬的铜相关肝炎是一种常染色体隐性遗传方式。此外，一些从国外进口的雄性大麦町犬可能参与了该病在日本的发生。
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