Department of Hematology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Trauma Center/Department of Emergency and Trauma Surgery, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
Clin Exp Ophthalmol. 2022 Aug;50(6):615-631. doi: 10.1111/ceo.14122. Epub 2022 Jul 5.
Studies on the epidemiology and prognosis of primary ocular adnexal lymphoma (POAL) are scarce for its low occurrence. The goal of our research was to assess the epidemiologic characteristics, prognostic variables and survival of POAL patients.
The Surveillance, Epidemiology and End Results (SEER) database was used to collect data on patients identified with POAL from 1975 to 2011 and the incidence rate of POAL from 1975 to 2017. To discover independent predictive markers for overall survival (OS) and disease-specific survival (DSS), multivariable Cox regression analysis was utilised. The independent prognostic factors found by multivariate Cox regression analysis were used to generate a nomogram.
A total of 2839 patients were diagnosed with POAL, with an average age of 64.1 years. The total incidence of POAL was 2.51/1000000 (according to the overall adjustment of the 2000 American standard) from 1975 to 2017, and the annual percentage change (APC) was 2.47 (95% confidence interval 1.64-3.32, p < 0.05), showing a sharp upward trend. After multivariate Cox regression analysis, age, gender, year of diagnosis, marital status, primary site, laterality, pathological type and treatment strategy were evaluated as independent prognostic factors of OS or DSS (p < 0.05). A nomogram was constructed to forecast the DSS of 1, 3, 5 and 10 years. The concordance index (C-index) and the calibration plots demonstrated the robustness and accuracy of the nomogram.
Although POAL is sporadic, the incidence has generally increased in the past 36 years. In recent years, survival rates have risen, and radiotherapy can render better OS and DSS. The nomogram specially made for POAL is robust and precise in predicting the DSS of 1, 3, 5 and 10 years.
由于原发性眼附属器淋巴瘤（POAL）的发病率较低，因此对其流行病学和预后的研究很少。我们的研究目的是评估 POAL 患者的流行病学特征、预后变量和生存情况。
我们使用监测、流行病学和最终结果（SEER）数据库收集了 1975 年至 2011 年期间被诊断为 POAL 的患者数据以及 1975 年至 2017 年期间的 POAL 发病率。为了发现总生存（OS）和疾病特异性生存（DSS）的独立预测标志物，我们使用了多变量 Cox 回归分析。多变量 Cox 回归分析发现的独立预后因素用于生成列线图。
共诊断出 2839 例 POAL 患者，平均年龄为 64.1 岁。1975 年至 2017 年期间，POAL 的总发病率为 2.51/1000000（根据 2000 年美国标准的总体调整），年变化百分比（APC）为 2.47（95%置信区间 1.64-3.32，p<0.05），呈明显上升趋势。经过多变量 Cox 回归分析，年龄、性别、诊断年份、婚姻状况、原发部位、侧别、病理类型和治疗策略被评估为 OS 或 DSS 的独立预后因素（p<0.05）。构建了一个列线图来预测 1、3、5 和 10 年的 DSS。一致性指数（C 指数）和校准图表明该列线图具有稳健性和准确性。
尽管 POAL 较为罕见，但在过去 36 年中，其发病率总体呈上升趋势。近年来，生存率有所提高，放疗可以获得更好的 OS 和 DSS。专门为 POAL 制作的列线图在预测 1、3、5 和 10 年 DSS 方面具有稳健性和精确性。
