Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.
Clinical Trial Center Würzburg, University Hospital Würzburg, Würzburg, Germany.
J Dtsch Dermatol Ges. 2022 Jun;20(6):798-805. doi: 10.1111/ddg.14738. Epub 2022 Jun 3.
Bullous pemphigoid (BP) is associated with neuropsychiatric disorders. Other comorbid diseases are discussed controversially. We evaluated the prevalence of comorbidity in BP patients in a representative area of Germany.
Medical files of all BP patients treated at the Department of Dermatology, University Hospital Würzburg, Germany, between June 2002 and May 2013 were retrospectively reviewed. Bullous pemphigoid was diagnosed based on established criteria. For each patient, two controls were individually matched. Records were evaluated for age, sex, laboratory values, concomitant medication and comorbidity. Conditional logistic regression, multivariable regression analysis and complex regression models were performed to compare results.
300 BP patients were identified and compared to 583 controls. Bullous pemphigoid was associated with neuropsychiatric disorders as well as laboratory abnormalities including leukocytosis and eosinophilia. Importantly, a highly significant association of BP with anemia (OR 2.127; 95 % CI 1.532-2.953) and renal impairment (OR 2.218; 95 % CI 1.643-2.993) was identified. No association was found with malignancy and arterial hypertension.
Our data revealed an increased frequency of anemia and renal impairment in BP patients. In accordance with previous studies the strong association for neuropsychiatric disorders was confirmed (p < 0.0005).
大疱性类天疱疮（BP）与神经精神障碍有关。其他合并症存在争议。我们评估了德国代表性地区 BP 患者合并症的患病率。
回顾性分析了 2002 年 6 月至 2013 年 5 月期间在德国维尔茨堡大学医院皮肤科接受治疗的所有 BP 患者的病历。根据既定标准诊断为大疱性类天疱疮。为每位患者匹配了两名单独的对照者。记录评估了年龄、性别、实验室值、伴随用药和合并症。进行了条件逻辑回归、多变量回归分析和复杂回归模型来比较结果。
确定了 300 名 BP 患者，并与 583 名对照者进行了比较。大疱性类天疱疮与神经精神障碍以及包括白细胞增多和嗜酸性粒细胞增多在内的实验室异常有关。重要的是，发现 BP 与贫血（OR 2.127；95%CI 1.532-2.953）和肾功能损害（OR 2.218；95%CI 1.643-2.993）高度相关。未发现与恶性肿瘤和动脉高血压相关。
我们的数据显示 BP 患者贫血和肾功能损害的频率增加。与之前的研究一致，证实了神经精神障碍的强相关性（p<0.0005）。
