Cagnina A, Chabot O, Davin L, Lempereur M, Maréchal P, Oury C, Lancellotti P
Service de Cardiologie, CHU Liège, Belgique.
GIGA Cardiovasculaire, ULiège, Belgique.
Rev Med Liege. 2022 May;77(5-6):302-309.
Chronic inflammation is recognized as a contributing factor to the development, progression and complications of atherosclerosis. The inflammatory nature of atherosclerosis has been proven by the presence of inflammatory cells, cytokines and chemokines at all stages of the disease. There is a widely accepted association between cardiovascular events and serum inflammatory markers, such as CRP, IL-6 and IL-1? produced via the inflammasome pathway. The involvement of inflammatory processes in atherosclerosis and progress in the therapeutic strategy are detailed in the article.
慢性炎症被认为是动脉粥样硬化发生、发展及并发症的一个促成因素。动脉粥样硬化的炎症本质已通过疾病各阶段炎症细胞、细胞因子和趋化因子的存在得到证实。心血管事件与血清炎症标志物(如通过炎性小体途径产生的CRP、IL-6和IL-1β)之间存在广泛认可的关联。本文详细阐述了炎症过程在动脉粥样硬化中的作用以及治疗策略的进展。