The Francis Crick Institute, Midland Road, London, NW1 1AT, UK.
Centre for Mechanochemical Cell Biology, Warwick Medical School, Gibbet Hill Road, Coventry, CV4 7AL, UK.
Cell Mol Life Sci. 2022 Jun 3;79(6):335. doi: 10.1007/s00018-022-04371-6.
Membrane traffic controls the movement of proteins and lipids from one cellular compartment to another using a system of transport vesicles. Intracellular nanovesicles (INVs) are a newly described class of transport vesicles. These vesicles are small, carry diverse cargo, and are involved in multiple trafficking steps including anterograde traffic and endosomal recycling. An example of a biological process that they control is cell migration and invasion, due to their role in integrin recycling. In this review, we describe what is known so far about these vesicles. We discuss how INVs may integrate into established membrane trafficking pathways using integrin recycling as an example. We speculate where in the cell INVs have the potential to operate and we identify key questions for future investigation.
膜运输系统使用运输囊泡来控制蛋白质和脂质从一个细胞区室到另一个细胞区室的运动。细胞内纳米囊泡（INV）是一种新描述的运输囊泡。这些囊泡体积小，携带多种货物，并参与包括正向运输和内体再循环在内的多个运输步骤。它们控制的一个生物学过程的例子是细胞迁移和侵袭，这是由于它们在整合素再循环中的作用。在这篇综述中，我们描述了目前对这些囊泡的了解。我们讨论了 INV 如何通过整合素再循环为例整合到已建立的膜运输途径中。我们推测 INV 在细胞中的哪些部位具有潜在的作用，并确定了未来研究的关键问题。
