Deming Department of Medicine, School of Medicine, Tulane University, New Orleans, LA, USA.
Methods Mol Biol. 2022;2500:83-103. doi: 10.1007/978-1-0716-2325-1_8.
With the advances of mass spectrometry (MS) techniques, top-down MS-based proteomics has gained increasing attention because of its advantages over bottom-up MS in studying complex proteoforms. TopPIC Suite is a widely used software package for top-down MS-based proteoform identification and quantification. Here, we present the methods for top-down MS data analysis using TopPIC Suite.
随着质谱 (MS) 技术的进步，基于自上而下的 MS 的蛋白质组学因其在研究复杂蛋白质形式方面优于基于自下而上的 MS 的优点而受到越来越多的关注。TopPIC Suite 是一个广泛用于基于自上而下的 MS 的蛋白质形式鉴定和定量的软件包。在这里，我们介绍了使用 TopPIC Suite 进行自上而下的 MS 数据分析的方法。
