Department of Radiation Oncology and Image-Applied Therapy, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
PLoS One. 2022 Jun 3;17(6):e0269463. doi: 10.1371/journal.pone.0269463. eCollection 2022.
Marital status has been proposed as a promising prognostic factor in many malignancies, including non-small-cell lung cancer (NSCLC). However, its prognostic value is still unclear for individual non-surgical treatments for stage I NSCLC. This study investigated the prognostic value of marital status in patients with early-stage NSCLC treated with stereotactic body radiotherapy (SBRT). Patients with early-stage NSCLC treated with SBRT between January 2003 and March 2014 at our institute were enrolled, and marital status at the time of SBRT was investigated. Propensity score matching (PSM) was applied to reduce potential selection bias between the married and unmarried groups. Two hundred and forty patients (median age 77 years; 152 married, 87 unmarried) were analyzed. The unmarried included higher proportions of the elderly, women, never smokers, and those with decreased pulmonary function compared to the married. PSM identified 53 matched pairs of married and unmarried patients, with no significant difference in patient background parameters. The 5-year overall survival (OS) was 52.8% and 46.9% in the married and unmarried groups, respectively (P = 0.26). There was no significant difference in NSCLC death or non-NSCLC death between the two groups (P = 0.88 and 0.30, respectively). There was no significant difference in OS between married and unmarried male patients (n = 85, 5-year OS, 52.6% vs. 46.0%; P = 0.42) and between married and unmarried female patients (n = 21, 54.5% vs. 50.0%; P = 0.44). In conclusion, marital status was not associated with OS in patients receiving SBRT for early-stage NSCLC.
婚姻状况已被提出作为许多恶性肿瘤的一个有前途的预后因素，包括非小细胞肺癌（NSCLC）。然而，对于非手术治疗的 I 期 NSCLC 来说，其预后价值尚不清楚。本研究调查了婚姻状况对接受立体定向体部放疗（SBRT）治疗的早期 NSCLC 患者的预后价值。本研究纳入了 2003 年 1 月至 2014 年 3 月期间在我院接受 SBRT 治疗的早期 NSCLC 患者，并调查了 SBRT 时的婚姻状况。应用倾向评分匹配（PSM）来减少已婚和未婚组之间潜在的选择偏倚。共分析了 240 例患者（中位年龄 77 岁；152 例已婚，87 例未婚）。与已婚组相比，未婚组中老年人、女性、从不吸烟者和肺功能下降者的比例更高。PSM 识别了 53 对匹配的已婚和未婚患者，两组患者背景参数无显著差异。已婚组和未婚组的 5 年总生存率（OS）分别为 52.8%和 46.9%（P=0.26）。两组之间 NSCLC 死亡和非 NSCLC 死亡无显著差异（P=0.88 和 0.30）。接受 SBRT 治疗的早期 NSCLC 男性患者（n=85）和女性患者（n=21）中，已婚和未婚患者的 OS 也无显著差异（5 年 OS，52.6% vs. 46.0%；P=0.42 和 54.5% vs. 50.0%；P=0.44）。总之，在接受 SBRT 治疗的早期 NSCLC 患者中，婚姻状况与 OS 无关。
