Sosis M, Larijani G E, Marr A T
Anesth Analg. 1987 Apr;66(4):329-32.
Priming with atracurium was evaluated by dividing 39 patients into 2 groups. All received 0.2 mg IV glycopyrrolate and fentanyl, 50 micrograms IV. Group 1 received saline, group 2 received 0.06 mg/kg atracurium and a stop watch was started. After 3.5 min the patients were asked to lift their heads and maximum negative inspiratory pressure (MIP) was measured. Anesthesia then commenced with thiopental and a twitch monitor was applied to the ulnar nerve. At 5 min group 1 received 0.36 mg/kg atracurium and group 2 was given 0.30 mg/kg atracurium. At 6.5 min intubation was accomplished in all but one patient in group 1 and all but one in group 2. Mean T4/T1 ratios at 90 sec were 0.73 in group 1 and 0.51 in group 2. This difference was statistically significant (P less than 0.001). Bucking on the endotracheal tube occurred in 72% of patients in group 1 and 62% of those in group 2 (not significant). Intubating conditions were "excellent" in 56% of those in group 1 and 75% in group 2 (not significant). "Good" conditions were seen in 33% of group 1 and 15% of group 2 patients (not significant). "Fair" conditions were noted in 6% of patients in group 1 and 5% of group 2 patients (not significant). The time to maximum twitch depression was 11.3 min and 11.5 min in groups 1 and 2 respectively (not significant). All patients in group 1 could sustain head lift whereas four patients in group 2 could not (not significant).(ABSTRACT TRUNCATED AT 250 WORDS)
将39例患者分为两组，对阿曲库铵预充效果进行评估。所有患者均静脉注射0.2mg格隆溴铵和50微克芬太尼。第一组接受生理盐水，第二组接受0.06mg/kg阿曲库铵，同时开始计时。3.5分钟后，要求患者抬头并测量最大吸气负压（MIP）。然后用硫喷妥钠开始麻醉，并对尺神经应用肌颤搐监测仪。5分钟时，第一组接受0.36mg/kg阿曲库铵，第二组接受0.30mg/kg阿曲库铵。6.5分钟时，除第一组一名患者和第二组一名患者外，其余患者均完成插管。90秒时，第一组平均T4/T1比值为0.73，第二组为0.51。这种差异具有统计学意义（P＜0.001）。第一组72%的患者和第二组62%的患者出现气管导管呛咳（无统计学意义）。第一组56%的患者和第二组75%的患者插管条件为“优”（无统计学意义）。第一组33%的患者和第二组15%的患者插管条件为“良”（无统计学意义）。第一组6%的患者和第二组5%的患者插管条件为“中”（无统计学意义）。第一组和第二组达到最大颤搐抑制的时间分别为11.3分钟和11.5分钟（无统计学意义）。第一组所有患者都能持续抬头，而第二组有四名患者不能（无统计学意义）。（摘要截选至250字）
