Bougas Lykourgos, Byron Joseph, Budker Dmitry, Williams Jonathan
Institut für Physik, Johannes Gutenberg-Universität Mainz, Mainz, Germany.
Max-Planck-Institut für Chemie, Mainz, Germany.
Sci Adv. 2022 Jun 3;8(22):eabm3749. doi: 10.1126/sciadv.abm3749.
Chiral analysis is central for scientific advancement in the fields of chemistry, biology, and medicine. It is also indispensable in the development and quality control of chiral compounds in the chemical and pharmaceutical industries. Here, we present the concept of absolute optical chiral analysis, as enabled by cavity-enhanced polarimetry, which allows for accurate unambiguous enantiomeric characterization and enantiomeric excess determination of chiral compounds within complex mixtures at trace levels, without the need for calibration, even in the gas phase. Our approach and technology enable the absolute postchromatographic chiral analysis of complex gaseous mixtures, the rapid quality control of complex mixtures containing chiral volatile compounds, and the online in situ observation of chiral volatile emissions from a plant under stress.
手性分析对于化学、生物学和医学领域的科学进步至关重要。在化学和制药行业中，它对于手性化合物的开发和质量控制也是不可或缺的。在此，我们提出了绝对光学手性分析的概念，这是通过腔增强偏振imetry实现的，它能够在无需校准的情况下，对复杂混合物中痕量水平的手性化合物进行准确无误的对映体表征和对映体过量测定，甚至在气相中也能做到。我们的方法和技术能够对复杂气态混合物进行绝对的色谱后手性分析，对含有手性挥发性化合物的复杂混合物进行快速质量控制，并对处于胁迫状态下的植物的手性挥发性排放进行在线原位观测。
