肥胖的长新冠患者在峰值运动时表现出异常的过度通气反应和气体交换受损。
Obese patients with long COVID-19 display abnormal hyperventilatory response and impaired gas exchange at peak exercise.
机构信息
Department of Neurosciences, Division of Functional Explorations, University Hospital of Martinique, Fort de France, 97200, France.
Cardiovascular Research Team, Université des Antilles, Fort de France, EA, 7525, France.
出版信息
Future Cardiol. 2022 Jul;18(7):577-584. doi: 10.2217/fca-2022-0017. Epub 2022 Jun 6.
Abstract
To analyze the impact of obesity on cardiopulmonary response to exercise in people with chronic post-COVID-19 syndrome. Consecutive subjects with chronic post-COVID syndrome 6 months after nonsevere acute infection were included. All patients received a complete clinical evaluation, lung function tests and cardiopulmonary exercise testing. A total of 51 consecutive patients diagnosed with chronic post-COVID-19 were enrolled in this study. More than half of patients with chronic post-COVID-19 had a significant alteration in aerobic exercise capacity (VOpeak) 6 months after hospital discharge. Obese long-COVID-19 patients also displayed a marked reduction of oxygen pulse (Opulse). Obese patients were more prone to have pathological pulmonary limitation and pulmonary gas exchange impairment to exercise compared with nonobese COVID-19 patients.
摘要
分析肥胖对慢性新冠后综合征患者运动心肺反应的影响。连续纳入急性非重症感染后 6 个月的慢性新冠后综合征患者。所有患者均接受完整的临床评估、肺功能检查和心肺运动试验。本研究共纳入 51 例连续诊断为慢性新冠后综合征的患者。超过一半的慢性新冠后综合征患者在出院后 6 个月时有氧运动能力（VOpeak）显著改变。肥胖的新冠后患者的氧脉冲（Opulse）也明显降低。与非肥胖新冠患者相比，肥胖患者更容易出现运动时病理性肺限制和肺气体交换受损。
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