长新冠患者的运动不耐受与氧摄取受损有关。
Exercise intolerance associated with impaired oxygen extraction in patients with long COVID.
机构信息
Department of Rehabilitation and Regenerative Medicine, Columbia University College of Physicians and Surgeons, USA.
Department of Population Health, New York University Grossman School of Medicine, USA.
出版信息
Respir Physiol Neurobiol. 2023 Jul;313:104062. doi: 10.1016/j.resp.2023.104062. Epub 2023 Apr 17.
OBJECTIVE
Chronic mental and physical fatigue and post-exertional malaise are the more debilitating symptoms of long COVID-19. The study objective was to explore factors contributing to exercise intolerance in long COVID-19 to guide development of new therapies. Exercise capacity data of patients referred for a cardiopulmonary exercise test (CPET) and included in a COVID-19 Survivorship Registry at one urban health center were retrospectively analyzed.
RESULTS
Most subjects did not meet normative criteria for a maximal test, consistent with suboptimal effort and early exercise termination. Mean O pulse peak % predicted (of 79 ± 12.9) was reduced, supporting impaired energy metabolism as a mechanism of exercise intolerance in long COVID, n = 59. We further identified blunted rise in heart rate peak during maximal CPET. Our preliminary analyses support therapies that optimize bioenergetics and improve oxygen utilization for treating long COVID-19.
目的
慢性精神和身体疲劳以及劳累后不适是长新冠更具致残性的症状。本研究旨在探讨导致长新冠运动不耐受的因素，以指导新疗法的开发。对因心肺运动试验（CPET）就诊并被纳入一家城市健康中心新冠康复登记处的患者的运动能力数据进行了回顾性分析。
结果
大多数患者的测试未达到最大测试的标准，这与测试用力不足和早期运动终止有关。平均 O 脉冲峰值预测值（79±12.9）降低，支持能量代谢受损是长新冠运动不耐受的机制，n=59。我们进一步发现，在最大 CPET 期间，心率峰值的上升变平。我们的初步分析支持优化生物能量学和提高氧气利用率的治疗方法，以治疗长新冠。
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