Nwankwo Henry, Mason James, Costa Matthew L, Parsons Nicholas, Redmond Anthony, Parsons Helen, Haque Aminul, Kearney Rebecca S
Warwick Clinical Trials Unit, University of Warwick, Coventry, UK.
Oxford Trauma and Emergency Care, Nuffield Department of Rheumatology, Musculoskeletal and Orthopaedic Sciences, University of Oxford, Oxford, UK.
Bone Jt Open. 2022 Jun;3(6):455-462. doi: 10.1302/2633-1462.36.BJO-2022-0036.
To compare the cost-utility of removable brace compared with cast in the management of adult patients with ankle fracture.
A within-trial economic evaluation conducted from the UK NHS and personnel social services (PSS) perspective. Health resources and quality-of-life data were collected as part of the Ankle Injury Rehabilitation (AIR) multicentre, randomized controlled trial over a 12-month period using trial case report forms and patient-completed questionnaires. Cost-utility analysis was estimated in terms of the incremental cost per quality adjusted life year (QALY) gained. Estimate uncertainty was explored by bootstrapping, visualized on the incremental cost-effectiveness ratio plane. Net monetary benefit and probability of cost-effectiveness were evaluated at a range of willingness-to-pay thresholds and visualized graphically.
The incremental cost and QALYs of using brace over a 12-month period were £46.73 (95% confidence interval (CI) £-9 to £147) and 0.0141 (95% CI -0.005 to 0.033), respectively. The cost per QALY gained was £3,318. The probability of brace being cost-effective at a £30,000 per QALY willingness-to-pay threshold was 88%. The results remained robust to a range of sensitivity analyses.
This within-trial economic evaluation found that it is probable that using a removable brace provides good value to the NHS when compared to cast, in the management of adults with ankle fracture. Cite this article: 2022;3(6):455-462.
比较在成年踝关节骨折患者治疗中,可拆除支具与石膏固定的成本效益。
从英国国民健康服务体系(NHS)和个人社会服务(PSS)的角度进行试验内经济评估。作为踝关节损伤康复(AIR)多中心随机对照试验的一部分,在12个月期间使用试验病例报告表和患者填写的问卷收集健康资源和生活质量数据。成本效益分析以每获得一个质量调整生命年(QALY)的增量成本来估计。通过自举法探索估计的不确定性,并在增量成本效益比平面上进行可视化。在一系列支付意愿阈值下评估净货币效益和成本效益概率,并以图形方式呈现。
在12个月期间使用支具的增量成本和QALY分别为46.73英镑(95%置信区间(CI)为-9英镑至147英镑)和0.0141(95%CI为-0.005至0.033)。每获得一个QALY的成本为3318英镑。在每QALY支付意愿阈值为30000英镑时,支具具有成本效益的概率为88%。一系列敏感性分析的结果仍然稳健。
这项试验内经济评估发现,在成年踝关节骨折患者的治疗中,与石膏固定相比,使用可拆除支具对NHS来说可能具有良好的价值。引用本文:2022;3(6):455 - 462。