Washington University Sleep Medicine Center, Department of Neurology, Washington University in St. Louis School of Medicine, 1600 S. Brentwood Boulevard, #600, St. Louis, MO 63144, USA.
Sleep Med Clin. 2022 Jun;17(2):307-314. doi: 10.1016/j.jsmc.2022.02.009. Epub 2022 Apr 22.
Patients suffering from neurodegenerative conditions frequently report sleep complaints, such as insomnia and excessive daytime sleepiness. These symptoms are likely multifactorial, caused by their underlying neurologic disorder and also by medications and other comorbidities associated with the progressive condition. A detailed history, sleep logs, actigraphy, or polysomnography may be necessary to properly diagnosis and manage these patients. Improvement in sleep may result in improvement in neurologic symptoms and quality of life in this population. There is growing evidence that disrupted sleep may lead to acceleration in the progression of the neurodegenerative disorder and may play a role in the pathogenesis.
患有神经退行性疾病的患者经常会报告睡眠问题，如失眠和白天过度嗜睡。这些症状可能是多因素的，既由潜在的神经疾病引起，也由与进行性疾病相关的药物和其他合并症引起。详细的病史、睡眠日志、活动记录仪或多导睡眠图可能是正确诊断和治疗这些患者所必需的。改善睡眠可能会改善该人群的神经症状和生活质量。越来越多的证据表明，睡眠中断可能导致神经退行性疾病的进展加速，并可能在发病机制中发挥作用。
