Malhotra Raman K
Department of Neurology, Saint Louis University School of Medicine, Monteleone Hall, 1438 South Grand Boulevard, St Louis, MO 63104, USA.
Sleep Med Clin. 2018 Mar;13(1):63-70. doi: 10.1016/j.jsmc.2017.09.006. Epub 2017 Nov 10.
Sleep disorders are commonly found in cerebral degenerative disorders. The sleep disorders may be caused by the primary symptoms of the neurologic disease or may result from damage to sleep-controlling centers in the brain. Common sleep disorders found in this population include insomnia, hypersomnia, sleep apnea, restless legs syndrome, circadian rhythm disorders, and rapid eye movement sleep behavior disorder. The latter disorder can present years before other neurologic symptoms or signs are present, serving as a precursor of neurodegenerative conditions. There is growing evidence that poor sleep leads to acceleration in the progression of the neurodegenerative disorder and may play a role in pathogenesis.
睡眠障碍在脑退行性疾病中很常见。睡眠障碍可能由神经疾病的主要症状引起，也可能是由于大脑中睡眠控制中枢受损所致。该人群中常见的睡眠障碍包括失眠、嗜睡、睡眠呼吸暂停、不宁腿综合征、昼夜节律紊乱和快速眼动睡眠行为障碍。后一种障碍可能在出现其他神经症状或体征之前数年就已出现，是神经退行性疾病的先兆。越来越多的证据表明，睡眠不佳会导致神经退行性疾病进展加速，并可能在发病机制中起作用。
