Department of Pediatrics, University of Minnesota Medical School, Academic Office Building, 2450 Riverside Avenue S AO-401, Minneapolis, MN 55454, USA; Masonic Institute for the Developing Brain, 2025 East River Parkway, Minneapolis, MN 55414.
Department of Pediatrics, University of Minnesota Medical School, Academic Office Building, 2450 Riverside Avenue S AO-401, Minneapolis, MN 55454, USA; Masonic Institute for the Developing Brain, 2025 East River Parkway, Minneapolis, MN 55414.
Clin Perinatol. 2022 Jun;49(2):405-426. doi: 10.1016/j.clp.2022.02.008. Epub 2022 Apr 21.
This article summarizes the available evidence reporting the relationship between perinatal dysglycemia and long-term neurodevelopment. We review the physiology of perinatal glucose metabolism and discuss the controversies surrounding definitions of perinatal dysglycemia. We briefly review the epidemiology of hypoglycemia and hyperglycemia in fetal, preterm, and term infants. We discuss potential pathophysiologic mechanisms contributing to dysglycemia and its effect on neurodevelopment. We highlight current strategies to prevent and treat dysglycemia in the context of neurodevelopmental outcomes. Finally, we discuss areas of future research and the potential role of continuous glucose monitoring.
本文总结了现有的关于围产期糖代谢紊乱与长期神经发育关系的证据。我们回顾了围产期葡萄糖代谢的生理学，并讨论了围产期糖代谢紊乱定义方面的争议。我们简要回顾了胎儿期、早产儿和足月儿低血糖和高血糖的流行病学。我们讨论了导致糖代谢紊乱及其对神经发育影响的潜在病理生理机制。我们重点介绍了目前在神经发育结局方面预防和治疗糖代谢紊乱的策略。最后，我们讨论了未来的研究领域和连续血糖监测的潜在作用。
