Blodgett D J, Bevill R F
Am J Vet Res. 1987 Mar;48(3):530-4.
Pharmacokinetics of Se were evaluated in 24 female crossbred sheep, 8 to 14 months of age, after toxic doses of Se were administered. Five groups of 4 sheep each were given 0.4, 0.6, 0.7, 0.8, or 1 mg of Se/kg of body weight, IM. Nine of these sheep died within 36 hours after Se administration. Blood Se disappearance curves were triphasic for the 11 sheep that lived for at least 36 hours after Se administration and were biphasic for the 9 sheep that died within 36 hours. The lambda 2 rate constants of Se disposition after IM administration indicated a dose dependency. Sheep given 0.4, 0.6, 0.7, or 0.8 mg of Se/kg had lambda 2 rate constants of 0.110, 0.079, 0.046, and 0.034 hour-1, respectively (r2 = 0.97). The respective half-lives of the 2nd distributive phase after IM administration were 6.3, 8.8, 15.1, and 20.4 hours. In the 11 sheep that had triphasic pharmacokinetics, the mean lambda 3 elimination rate was 0.0011 hour-1. Four additional sheep were given 0.7 mg of Se/kg, IV. These sheep survived and had blood Se disappearance curves that were triphasic. In the 4 sheep given Se IV, the mean lambda 3 elimination rate was 0.0020 hour-1, which represented a biological half-life of 354 hours or 14.7 days.
在给24只8至14月龄的雌性杂交绵羊注射中毒剂量的硒后，对其进行了硒的药代动力学评估。将24只绵羊分成五组，每组4只，分别肌肉注射0.4、0.6、0.7、0.8或1毫克硒/千克体重。其中9只绵羊在注射硒后36小时内死亡。对于注射硒后存活至少36小时的11只绵羊，其血硒消失曲线为三相；对于在36小时内死亡的9只绵羊，其血硒消失曲线为双相。肌肉注射后硒处置的λ2速率常数显示出剂量依赖性。给予0.4、0.6、0.7或0.8毫克硒/千克的绵羊，其λ2速率常数分别为0.110、0.079、0.046和0.034小时-1（r2 = 0.97）。肌肉注射后第二分布相的各自半衰期分别为6.3、8.8、15.1和20.4小时。在具有三相药代动力学的11只绵羊中，平均λ3消除速率为0.0011小时-1。另外4只绵羊静脉注射0.7毫克硒/千克。这些绵羊存活下来，其血硒消失曲线为三相。在静脉注射硒的4只绵羊中，平均λ3消除速率为0.0020小时-1，这代表生物半衰期为354小时或14.7天。
