Hematology, Oncology, Transplant Program, Alberta Children's Hospital, 28 Oki Dr NW, Calgary, AB T3B 6A8, Canada.
Hematology, Oncology, Transplant Program, Alberta Children's Hospital, 28 Oki Dr NW, Calgary, AB T3B 6A8, Canada.
Blood Rev. 2022 Nov;56:100982. doi: 10.1016/j.blre.2022.100982. Epub 2022 May 25.
This review had three aims: 1) describe the measures used to assess health-related quality of life (HRQL) in pediatric patients diagnosed with sickle cell disease (SCD); 2) document the biopsychosocial factors related to HRQL in pediatric patients diagnosed with SCD; and 3) complete a meta-analysis comparing HRQL in pediatric patients diagnosed with SCD to healthy controls. Included studies were published in English, quantitatively assessed HRQL as a primary aim, in both SCD and controls, and included participants between 0 and 21 years of age. The final review included 66 articles, with a total of 8642 participants with SCD, 4 months-21 years of age, and 62,458 controls, 5-27 years of age. HRQL was predominately measured using the Pediatric Quality of Life Inventory Generic Core and Sickle Cell Disease Module. Meta-analyses revealed children with SCD had significantly worse HRQL compared to healthy controls (standardized mean difference = -0.93, 95% CI = -1.25, -0.61, p < 0.00001). Worse HRQL was associated with more severe SCD, female sex, and pain. The findings indicate that children with SCD are at risk for worse HRQL compared to their healthy peers and their HRQL may be impacted by several biopsychosocial factors. Future research is needed to examine how sociocultural factors uniquely impact this population and their overall quality of life.
1）描述用于评估诊断为镰状细胞病（SCD）的儿科患者健康相关生活质量（HRQL）的措施；2）记录与诊断为 SCD 的儿科患者 HRQL 相关的生物心理社会因素；3）完成一项荟萃分析，比较诊断为 SCD 的儿科患者与健康对照组的 HRQL。纳入的研究以英文发表，主要定量评估 HRQL，同时纳入 SCD 和对照组的参与者，年龄在 0 至 21 岁之间。最终综述纳入 66 篇文章，共 8642 名 SCD 患者，年龄为 4 个月至 21 岁，62458 名对照者，年龄为 5 至 27 岁。HRQL 主要使用儿童生活质量问卷通用核心量表和镰状细胞病模块进行测量。荟萃分析显示，与健康对照组相比，SCD 患儿的 HRQL 明显更差（标准化均数差=−0.93，95%置信区间=−1.25，−0.61，p<0.00001）。更差的 HRQL 与更严重的 SCD、女性性别和疼痛有关。研究结果表明，与健康同龄人相比，SCD 患儿的 HRQL 较差，并且他们的 HRQL 可能受到多种生物心理社会因素的影响。未来的研究需要检查社会文化因素如何独特地影响这一人群及其整体生活质量。
