两种光生物调节方案对正畸诱导的炎症性牙根吸收的影响（一项随机对照临床试验）。

The influence of two photobiomodulation protocols on orthodontically induced inflammatory root resorption (a randomized controlled clinical trial).

机构信息

Department of Orthodontics, Faculty of Dentistry, Alexandria University, Champolion Street, Azarita, Alexandria, Egypt.

出版信息

BMC Oral Health. 2022 Jun 5;22(1):221. doi: 10.1186/s12903-022-02251-w.

BACKGROUND

Controversial results have been reported regarding the impact of photobiomodulation (PBM) on orthodontically induced inflammatory root resorption (OIIRR). The aim of this study was to evaluate the influence of two PBM protocols, one of them requiring a high application frequency (on days 0, 3, 7, 14, then every 2 weeks), while the second requires less frequent applications (every 3 weeks), on OIIRR accompanying orthodontic treatment.

METHODS

Twenty female patients were recruited for this randomized controlled trial, requiring the therapeutic extraction of maxillary first premolars, and they were randomly divided into 2 equal groups. In Group A, one side of the maxillary arch randomly received PBM on days 0, 3, 7, 14, and every 2 weeks thereafter, while in Group B, one side was randomly chosen to receive PBM every 3 weeks. The laser applied was a Diode laser with a wavelength of 980 nm, in a continuous mode. Canine retraction in both groups was carried out using closed-coil springs, delivering 150 g of force, and the force level was checked every 3 weeks, over a 12-week study period. Pre-retraction and post-retraction cone-beam computed tomography (CBCT) was done for the evaluation of OIIRR.

RESULTS

No significant differences in the amount of OIIRR have been reported between the laser and control sides in both groups A and B. Also, no significant differences have been reported between the laser sides in both groups.

CONCLUSIONS

Photobiomodulation does not affect OIIRR, whether by increasing or decreasing its occurrence, with both laser application protocols. Therefore, it can be stated that PBM does not result in root resorption less than the commonly observed range elicited with conventional orthodontic treatment, and that it has no effect on OIIRR. Trial registration Two Low-level Laser Irradiation Protocols on the Rate of Canine Retraction (NCT04926389), 15/06/2021-retrospectively registered. https://clinicaltrials.gov/ct2/show/NCT04926389 .

背景

光生物调节（PBM）对正畸诱导的炎症性牙根吸收（OIIRR）的影响结果存在争议。本研究旨在评估两种 PBM 方案的影响，一种方案需要高应用频率（在第 0、3、7、14 天，然后每 2 周一次），而另一种方案则需要较少的应用频率（每 3 周一次），以观察它们对正畸治疗伴随的 OIIRR 的影响。

方法

本随机对照试验共纳入 20 名女性患者，需要治疗性拔除上颌第一前磨牙，并将其随机分为两组。在 A 组中，上颌弓的一侧在第 0、3、7、14 天和此后每 2 周接受 PBM，而在 B 组中，一侧随机选择接受 PBM 每 3 周一次。应用的激光为波长 980nm 的二极管激光，连续模式。两组均使用闭合螺旋弹簧进行尖牙内收，施加 150g 的力，在 12 周的研究期间，每 3 周检查一次力水平。在尖牙内收前和内收后进行锥形束计算机断层扫描（CBCT）评估 OIIRR。

结果

在 A 组和 B 组中，激光侧和对照侧的 OIIRR 量均无显著差异。此外，两组的激光侧之间也没有报告显著差异。

结论

两种激光应用方案均不会影响 OIIRR 的发生，无论是增加还是减少。因此，可以说 PBM 不会导致根吸收少于常规正畸治疗所引起的常见范围，也不会对 OIIRR 产生影响。试验注册：两种低水平激光照射方案对犬牙内收率的影响（NCT04926389），2021 年 6 月 15 日-回顾性注册。https://clinicaltrials.gov/ct2/show/NCT04926389。