Erasme Hospital, Department of Psychiatry and Sleep Laboratory, Université libre de Bruxelles, ULB, Brussels, Belgium, Route de Lennik, 808, Anderlecht 1070, Belgium.
Erasme Hospital, Department of Psychiatry and Sleep Laboratory, Université libre de Bruxelles, ULB, Brussels, Belgium, Route de Lennik, 808, Anderlecht 1070, Belgium.
Psychiatry Res. 2022 Aug;314:114650. doi: 10.1016/j.psychres.2022.114650. Epub 2022 May 26.
Given the limited data in the literature, the aim of this study was to investigate the risk of relapse within 6 months associated with borderline personality disorder (BPD) in major depressed individuals treated with electroconvulsive therapy. Demographic and clinical data from 109 major depressed individuals with partial or complete response to electroconvulsive therapy recruited from the database of the Psychiatry Department of Erasme Hospital were analysed. Cox regression analyses were used to determine the risk of relapse within 6 months associated with BPD in major depressed individuals treated with electroconvulsive therapy. Relapses within 6 months were frequent (37.6%) in our sample of major depressed individuals treated with electroconvulsive therapy. After adjusting for major confounding factors, multivariate Cox regression analyses demonstrated that BPD was a risk factor for relapse within 6 months in major depressed individuals treated with electroconvulsive therapy. In our study, we demonstrated that BPD is associated with higher risk of relapse within 6 months in major depressed individuals treated with electroconvulsive therapy, which seems to justify a more systematic screening for BPD in order to allow the implementation of more effective prevention strategies for relapse within 6 months in this particular subpopulation.
鉴于文献中的数据有限，本研究旨在探讨电抽搐治疗后患有边缘型人格障碍（BPD）的重度抑郁症患者在 6 个月内复发的风险。从 Erasme 医院精神病学部数据库中招募了 109 名对电抽搐治疗有部分或完全反应的重度抑郁患者的人口统计学和临床数据进行了分析。Cox 回归分析用于确定电抽搐治疗后患有 BPD 的重度抑郁患者在 6 个月内复发的风险。在我们接受电抽搐治疗的重度抑郁患者样本中，6 个月内的复发很常见（37.6%）。在调整了主要混杂因素后，多变量 Cox 回归分析表明，BPD 是电抽搐治疗后重度抑郁患者 6 个月内复发的一个风险因素。在我们的研究中，我们证明了 BPD 与电抽搐治疗后重度抑郁患者 6 个月内复发的风险增加有关，这似乎证明了更系统地筛查 BPD 的合理性，以便为该特定亚群在 6 个月内的复发制定更有效的预防策略。
