Department of Anesthesiology and Pain Medicine, Rasool Akram Medical Complex, Iran University of Medical Sciences, Tehran, Iran.
Minimally Invasive Surgery Research Center, Department of Anesthesiology and Pain Medicine, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
BMC Res Notes. 2022 Jun 3;15(1):191. doi: 10.1186/s13104-022-06083-3.
We aimed to compare the effect of bupivacaine intraperitoneal with intra-abdominal bicarbonate in reducing postoperative pain in laparoscopic cholecystectomy.
In this double-blind randomized clinical trial study, 58 patients underwent laparoscopic cholecystectomy referred to a hospital in Tehran, Iran (2019), were assigned into three groups: at the end of the surgery, spraying 50 cc of bupivacaine 0.2% through the laparoscopic port; or rinsing the abdomen with 5.7% bicarbonate dissolved in 1000 cc of normal saline; or abdominal lavage with normal saline. Pain of patients was evaluated according to visual analogue scale criteria and means Ramsay score in recovery times, 2, 8 and 24 h and post-operative analgesia satisfaction score at 2 and 24 h were also evaluated. The mean age of range was 44.26 ± 13.13 years, 44 female patients and 14 male patients. The mean Ramsay score in recovery, 2, 8 and 24 h postoperative times was not significantly different among the groups. Comparing post-operative analgesic satisfaction scores in recovery, 2 and 24 h revealed no significant difference among the groups. We found that use of bupivacaine intraperitoneal and intra-abdominal bicarbonate decreased pain after laparoscopic cholecystectomy but the decrease was more in bupivacaine group than bicarbonate group.
Retrospectively registered, IRCT20180723040570N1; date of registration: 2019-06-24.
比较布比卡因腹腔内注射与腹腔内碳酸氢盐在减少腹腔镜胆囊切除术后疼痛的效果。
在这项双盲随机临床试验研究中，58 名接受腹腔镜胆囊切除术的患者被分配到三个组：手术结束时，通过腹腔镜端口喷洒 50cc0.2%布比卡因；或用 5.7%碳酸氢钠溶解在 1000cc 生理盐水冲洗腹腔；或用生理盐水冲洗腹腔。根据视觉模拟评分标准和 Ramsay 评分评估患者的疼痛，评估术后恢复时间、2、8 和 24 小时的平均 Ramsay 评分和术后 2 和 24 小时的镇痛满意度评分。患者的平均年龄为 44.26±13.13 岁，女性 44 例，男性 14 例。术后恢复、2、8 和 24 小时的平均 Ramsay 评分在各组之间无显著差异。比较术后恢复、2 和 24 小时的镇痛满意度评分，各组之间无显著差异。我们发现，腹腔内注射布比卡因和腹腔内碳酸氢盐均可减轻腹腔镜胆囊切除术后的疼痛，但布比卡因组的疼痛减轻程度大于碳酸氢盐组。
回顾性注册，IRCT20180723040570N1；注册日期：2019 年 6 月 24 日。
