人类胚胎模型破解对称破缺。

A human embryo model cracks symmetry breaking.

机构信息

Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Site, Cambridge CB2 3EG, UK; Centre for Trophoblast Research, University of Cambridge, Downing Site, Cambridge CB2 3EG, UK; Wellcome Trust - Medical Research Council Stem Cell Institute, University of Cambridge, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge CB2 0AW, UK.

出版信息

Cell Stem Cell. 2022 Jun 2;29(6):869-870. doi: 10.1016/j.stem.2022.05.009.

DOI:10.1016/j.stem.2022.05.009

PMID:35659870

Abstract

In this issue of Cell Stem Cell, Simunovic et al. (2022) establish embryoids by combining embryonic and extraembryonic components derived from human pluripotent stem cells. The embryoids resemble human embryos cultured to post-implantation stages in vitro with regard to morphology, symmetry breaking, and the formation of primitive streak-like cell types.

摘要

在本期《细胞-干细胞》中，Simunovic 等人（2022）通过将源自人类多能干细胞的胚胎和胚胎外成分结合，建立了类胚体。这些类胚体在形态、对称性破缺以及原始条纹样细胞类型的形成方面与体外培养的人类胚胎植入后阶段相似。