Novartis Institutes for BioMedical Research, Novartis Pharma AG, Cambridge, MA, USA.
Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland.
Cell Stem Cell. 2022 Jun 2;29(6):871-872. doi: 10.1016/j.stem.2022.05.008.
In this issue, Ben-Moshe et al. (2022) use spatiotemporally resolved single-cell and spatial transcriptomic profiling to dissect the multicellular dynamics enabling zonal liver regeneration. They highlight how pan-zonal compensatory hepatocyte proliferation, transient reprogramming of peri-injury hepatocytes, and concerted zonated action of different liver cell types orchestrate the healing process.
在本期中，Ben-Moshe 等人（2022 年）利用时空分辨的单细胞和空间转录组分析来剖析多细胞动态，从而实现肝区再生。他们强调了全肝区补偿性肝细胞增殖、损伤周边肝细胞的短暂重编程，以及不同类型肝细胞的协调作用如何共同调控愈合过程。
