空间和时间上定位的肝区再生的多细胞动力学。
Multicellular dynamics of zonal liver regeneration mapped in space and time.
机构信息
Novartis Institutes for BioMedical Research, Novartis Pharma AG, Cambridge, MA, USA.
Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland.
出版信息
Cell Stem Cell. 2022 Jun 2;29(6):871-872. doi: 10.1016/j.stem.2022.05.008.
In this issue, Ben-Moshe et al. (2022) use spatiotemporally resolved single-cell and spatial transcriptomic profiling to dissect the multicellular dynamics enabling zonal liver regeneration. They highlight how pan-zonal compensatory hepatocyte proliferation, transient reprogramming of peri-injury hepatocytes, and concerted zonated action of different liver cell types orchestrate the healing process.
在本期中，Ben-Moshe 等人（2022 年）利用时空分辨的单细胞和空间转录组分析来剖析多细胞动态，从而实现肝区再生。他们强调了全肝区补偿性肝细胞增殖、损伤周边肝细胞的短暂重编程，以及不同类型肝细胞的协调作用如何共同调控愈合过程。
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