Strang P, Lindgren A, Stendahl U
Anticancer Res. 1987 Jan-Feb;7(1):125-8.
Evaluations were made of the expression of blood group antigens, DNA content and S-phase rate in a prospective study of 97 patients with squamous cell carcinoma of the uterine cervix. No correlation was found between loss of ABH expression and ploidy level or the degree of proliferation, whereas correlations were found to age and stage. In 11 (42%) of 26 tumors with two or three detectable stemlines, distinct areas with disparate ABH staining patterns were found, indicating genotypic and phenotypic heterogeneity within these tumors. In tumors with one stemline significantly fewer such tumors were found (p less than 0.01). Twenty-four early recurrences (within 20-36 months) after treatment were found. High S-phase rates (greater than 20%) were associated with a significantly increased recurrence rate (p less than 0.05). Loss of ABH antigen expression or ploidy level were not statistically correlated to early recurrences.
对97例子宫颈鳞状细胞癌患者进行前瞻性研究，评估血型抗原表达、DNA含量和S期率。未发现ABH表达缺失与倍体水平或增殖程度之间存在相关性，而与年龄和分期存在相关性。在26个具有两个或三个可检测干细胞系的肿瘤中，有11个（42%）发现了具有不同ABH染色模式的不同区域，表明这些肿瘤内存在基因型和表型异质性。在具有一个干细胞系的肿瘤中，发现此类肿瘤明显较少（p<0.01）。发现24例治疗后早期复发（20-36个月内）。高S期率（大于20%）与复发率显著增加相关（p<0.05）。ABH抗原表达缺失或倍体水平与早期复发无统计学相关性。
