Morse G D, Lane T, Nairn D K, Deterding J, Curry J, Gal P
Antimicrob Agents Chemother. 1987 Feb;31(2):292-4. doi: 10.1128/AAC.31.2.292.
The pharmacokinetic characteristics of cefonicid, a highly protein-bound expanded-spectrum cephalosporin, were examined in six noninfected, clinically stable patients undergoing continuous ambulatory peritoneal dialysis. After a 1.0-g intravenous dose of cefonicid, the mean concentrations in serum were 105 +/- 25 and 35.6 +/- 14.4 micrograms/ml at 3 and 72 h, respectively. Despite a prolonged half-life in serum of 49.7 +/- 18 h, the penetration into peritoneal fluid was low. The average concentration in dialysate over the 72-h study period was 2.7 micrograms/ml. The serum clearance was 2.6 +/- 1.0 ml/min, and the distribution volume was 0.14 +/- 0.02 liter/kg. Dosage recommendations and clinical considerations for cefonicid use in continuous ambulatory peritoneal dialysis patients are discussed.
在6例接受持续性非卧床腹膜透析且未感染、临床状况稳定的患者中，对一种高蛋白结合率的广谱头孢菌素头孢尼西的药代动力学特征进行了研究。静脉注射1.0克头孢尼西后，血清中的平均浓度在3小时和72小时分别为105±25微克/毫升和35.6±14.4微克/毫升。尽管血清半衰期延长至49.7±18小时，但腹膜液中的渗透量较低。在72小时的研究期间，透析液中的平均浓度为2.7微克/毫升。血清清除率为2.6±1.0毫升/分钟，分布容积为0.14±0.02升/千克。讨论了头孢尼西在持续性非卧床腹膜透析患者中的用药建议和临床注意事项。
