Theodosakis Nicholas, Pagan Angel D, Fisher David E
Department of Dermatology, Massachusetts General Hospital, Boston, MA, USA.
Ponce Health Sciences University School of Medicine, Ponce, Puerto Rico, USA.
Curr Top Biochem Res. 2021;22:151-159.
The MiT/TFE family of proteins are important regulators of a number of metabolic processes. One of their most important roles is activating the autophagy pathway in the setting of nutrient deprivation or buildup of toxic metabolites. Their proper and improper functioning in this role has been linked to several types of disease, including cancer and multiple forms of neurodegeneration. In this review we will briefly outline what is known about individual family members' roles in regulating autophagy across a variety of contexts.
MiT/TFE 蛋白家族是许多代谢过程的重要调节因子。它们最重要的作用之一是在营养缺乏或有毒代谢产物积累的情况下激活自噬途径。它们在这一作用中的正常和异常功能与多种疾病有关，包括癌症和多种形式的神经退行性疾病。在这篇综述中，我们将简要概述关于各个家族成员在各种情况下调节自噬作用的已知情况。
