MiT/TFE家族成员在自噬调节中的作用。
The role of MiT/TFE family members in autophagy regulation.
作者信息
Theodosakis Nicholas, Pagan Angel D, Fisher David E
机构信息
Department of Dermatology, Massachusetts General Hospital, Boston, MA, USA.
Ponce Health Sciences University School of Medicine, Ponce, Puerto Rico, USA.
出版信息
Curr Top Biochem Res. 2021;22:151-159.
Abstract
The MiT/TFE family of proteins are important regulators of a number of metabolic processes. One of their most important roles is activating the autophagy pathway in the setting of nutrient deprivation or buildup of toxic metabolites. Their proper and improper functioning in this role has been linked to several types of disease, including cancer and multiple forms of neurodegeneration. In this review we will briefly outline what is known about individual family members' roles in regulating autophagy across a variety of contexts.
摘要
MiT/TFE 蛋白家族是许多代谢过程的重要调节因子。它们最重要的作用之一是在营养缺乏或有毒代谢产物积累的情况下激活自噬途径。它们在这一作用中的正常和异常功能与多种疾病有关，包括癌症和多种形式的神经退行性疾病。在这篇综述中，我们将简要概述关于各个家族成员在各种情况下调节自噬作用的已知情况。
相似文献
1
The role of MiT/TFE family members in autophagy regulation.
Curr Top Biochem Res. 2021;22:151-159.
2
Emerging roles and regulation of MiT/TFE transcriptional factors.
Cell Commun Signal. 2018 Jun 15;16(1):31. doi: 10.1186/s12964-018-0242-1.
3
MiT/TFE Family of Transcription Factors: An Evolutionary Perspective.
Front Cell Dev Biol. 2021 Jan 6;8:609683. doi: 10.3389/fcell.2020.609683. eCollection 2020.
4
HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution.
Autophagy. 2018;14(3):437-449. doi: 10.1080/15548627.2017.1419118. Epub 2018 Feb 17.
5
MiT/TFE Family Renal Cell Carcinoma.
Genes (Basel). 2023 Jan 5;14(1):151. doi: 10.3390/genes14010151.
6
Emerging roles of the MiT/TFE factors in cancer.
Trends Cancer. 2023 Oct;9(10):817-827. doi: 10.1016/j.trecan.2023.06.005. Epub 2023 Jul 1.
7
The complex relationship between TFEB transcription factor phosphorylation and subcellular localization.
EMBO J. 2018 Jun 1;37(11). doi: 10.15252/embj.201798804. Epub 2018 May 15.
8
MiT/TFE Family of Transcription Factors, Lysosomes, and Cancer.
Annu Rev Cancer Biol. 2019 Mar;3:203-222. doi: 10.1146/annurev-cancerbio-030518-055835. Epub 2018 Nov 28.
9
Oxidation of multiple MiT/TFE transcription factors links oxidative stress to transcriptional control of autophagy and lysosome biogenesis.
Autophagy. 2020 Sep;16(9):1683-1696. doi: 10.1080/15548627.2019.1704104. Epub 2019 Dec 18.
10
MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5.
J Cell Biol. 2015 Aug 3;210(3):435-50. doi: 10.1083/jcb.201501002.
引用本文的文献
1
PNKP targeting engages the autophagic machinery through STING and STAT3 to potentiate ferroptosis and chemotherapy in TNBC.
Redox Biol. 2025 Jul 22;86:103775. doi: 10.1016/j.redox.2025.103775.
2
Autophagy modulates glioblastoma cell sensitivity to Selinexor-mediated XPO1 inhibition.
Neuro Oncol. 2025 Jun 21;27(5):1210-1226. doi: 10.1093/neuonc/noae280.
3
Mitf, with Yki and STRIPAK-PP2A, is a key determinant of form and fate in the progenitor epithelium of the Drosophila eye.
Eur J Cell Biol. 2024 Jun;103(2):151421. doi: 10.1016/j.ejcb.2024.151421. Epub 2024 May 15.
本文引用的文献
1
Trehalose protects against cisplatin-induced cochlear hair cell damage by activating TFEB-mediated autophagy.
Biochem Pharmacol. 2022 Mar;197:114904. doi: 10.1016/j.bcp.2021.114904. Epub 2021 Dec 28.
2
HSF1-Dependent Autophagy Activation Contributes to the Survival of Melanocytes Under Oxidative Stress in Vitiligo.
J Invest Dermatol. 2022 Jun;142(6):1659-1669.e4. doi: 10.1016/j.jid.2021.11.007. Epub 2021 Nov 13.
3
TFE3 Regulates the Function of the Autophagy-Lysosome Pathway to Drive the Invasion and Metastasis of Papillary Thyroid Carcinoma.
Anal Cell Pathol (Amst). 2021 Oct 7;2021:3081491. doi: 10.1155/2021/3081491. eCollection 2021.
4
The impaired unfolded protein-premelanosome protein and transient receptor potential channels-autophagy axes in apoptotic melanocytes in vitiligo.
Pigment Cell Melanoma Res. 2022 Jan;35(1):6-17. doi: 10.1111/pcmr.13006. Epub 2021 Aug 10.
5
A protective role for autophagy in vitiligo.
Cell Death Dis. 2021 Mar 25;12(4):318. doi: 10.1038/s41419-021-03592-0.
6
TFEB Biology and Agonists at a Glance.
Cells. 2021 Feb 5;10(2):333. doi: 10.3390/cells10020333.
7
MiT/TFE Family of Transcription Factors: An Evolutionary Perspective.
Front Cell Dev Biol. 2021 Jan 6;8:609683. doi: 10.3389/fcell.2020.609683. eCollection 2020.
8
Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal storage and associated synaptic impairments in neurons.
Autophagy. 2021 Jun;17(6):1519-1542. doi: 10.1080/15548627.2020.1840796. Epub 2020 Nov 12.
9
MITF and TFEB cross-regulation in melanoma cells.
PLoS One. 2020 Sep 3;15(9):e0238546. doi: 10.1371/journal.pone.0238546. eCollection 2020.
10
TFE3, a potential therapeutic target for Spinal Cord Injury via augmenting autophagy flux and alleviating ER stress.
Theranostics. 2020 Jul 23;10(20):9280-9302. doi: 10.7150/thno.46566. eCollection 2020.
Zotero 插件