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新型羊主动脉弓缩窄模型中经导管主动脉瓣（Myval）的6个月评估

6-Month Evaluation of a Transcatheter Aortic Valve (Myval) in a Novel Ovine, Supra-Aortic Banding Model.

作者信息

Buszman Piotr P, Kachel Mateusz, Ceballos Carlos Fernandez, Łukasik Karolina, Domaradzki Wojciech, Pruski Maciej, Tellez Armando, Rousselle Serge, Konopko Marta, Glanc Michał, Kaźmierczak Paweł, Milewski Krzysztof P, Buszman Pawel E

机构信息

Department of Cardiology, Andrzej-Frycz Modrzewski Kraków University, Bielsko-Biała, Poland.

Center for Cardiovascular Research and Development, American Heart of Poland, Kostkowice, Poland.

出版信息

JACC Basic Transl Sci. 2022 May 11;7(5):486-495. doi: 10.1016/j.jacbts.2022.01.008. eCollection 2022 May.

DOI:10.1016/j.jacbts.2022.01.008
PMID:35663633
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9156430/
Abstract

The aim of the study was to evaluate a balloon expandable transcatheter heart valve (THV) system (Myval) at 6-month follow-up in ovine banding model. Eleven THV systems were implanted via carotid approach. There were 2 procedure-related deaths and 2 premature deaths. At 6 months all valves that completed follow-up (n = 7) were functional, with no significant regurgitation, calcification, thrombi, or vegetation. Mean pressure gradient was 21.9 ± 11 mm Hg, maximum velocity = 3.3 ± 1 m/s, and ejection fraction was 53.3 ± 6%. Myval THV showed optimal hemodynamic performance and biocompatibility.

摘要

本研究的目的是在绵羊结扎模型中对球囊可扩张经导管心脏瓣膜（THV）系统（Myval）进行6个月的随访评估。通过颈动脉途径植入了11个THV系统。有2例与手术相关的死亡和2例过早死亡。在6个月时，所有完成随访的瓣膜（n = 7）功能良好，无明显反流、钙化、血栓或赘生物。平均压力阶差为21.9±11 mmHg，最大流速为3.3±1 m/s，射血分数为53.3±6%。Myval THV显示出最佳的血流动力学性能和生物相容性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08fd/9156430/d147570a56bf/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08fd/9156430/3e81d709c1ae/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08fd/9156430/94c4417d2d87/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08fd/9156430/5fbd9b244e37/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08fd/9156430/c04d123dccf7/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08fd/9156430/bb96d1c4b4f2/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08fd/9156430/d147570a56bf/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08fd/9156430/3e81d709c1ae/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08fd/9156430/94c4417d2d87/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08fd/9156430/5fbd9b244e37/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08fd/9156430/c04d123dccf7/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08fd/9156430/bb96d1c4b4f2/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08fd/9156430/d147570a56bf/gr5.jpg

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