Enchev V G, Dobreva P V
Arch Geschwulstforsch. 1987;57(1):31-7.
Quantitative measurements of nuclear DNA content values have been evaluated in cytological smears from 33 women with normal breast, fibrocystic disease, fibroadenoma and different types of breast carcinomas. The DNA amount for normal breast was found to be in the diploid region. For fibrocystic disease and fibroadenoma the cytochemical data were established to range from diploid to tetraploid regions, with peaks at 2 C and 3 C, respectively. For the different types of malignant breast lesions the quantitative DNA amounts were presented in the various regions of the histograms: from diploid to tetraploid for papillar carcinomas and metaplastic carcinomas--fusiformcellular and epidermoid types, with peaks at 2 C; from diploid to octaploid for intracanalicular carcinomas with peaks at 2 C, 4 C and 6 C. Dynamic changes in the pathway from the normal to cancer have been determined after quantitative cytochemical measurements of various benign and malignant breast lesions.
对33名患有正常乳腺、纤维囊性疾病、纤维腺瘤和不同类型乳腺癌的女性的细胞学涂片进行了细胞核DNA含量值的定量测量。发现正常乳腺的DNA量处于二倍体区域。对于纤维囊性疾病和纤维腺瘤，细胞化学数据确定其范围从二倍体区域到四倍体区域，峰值分别在2C和3C。对于不同类型的恶性乳腺病变，定量DNA量呈现在直方图的不同区域：乳头状癌和化生癌（梭形细胞型和表皮样型）从二倍体到四倍体，峰值在2C；管内癌从二倍体到八倍体，峰值在2C、4C和6C。通过对各种良性和恶性乳腺病变进行定量细胞化学测量，确定了从正常到癌症过程中的动态变化。
