Fu Ningning, Zhu Ruilou, Zeng Shuang, Li Ningning, Zhang Jiaqiang
Department of Anesthesiology and Perioperative Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China.
Front Syst Neurosci. 2022 May 18;16:848362. doi: 10.3389/fnsys.2022.848362. eCollection 2022.
Oligodendrocytes (OLs) participate in the formation of myelin, promoting the propagation of action potentials, and disruption of their proliferation and differentiation leads to central nervous system (CNS) damage. As surgical techniques have advanced, there is an increasing number of children who undergo multiple procedures early in life, and recent experiments have demonstrated effects on brain development after a single or multiple anesthetics. An increasing number of clinical studies showing the effects of anesthetic drugs on the development of the nervous system may mainly reside in the connections between neurons, where myelin development will receive more research attention. In this article, we review the relationship between anesthesia exposure and the brain and OLs, provide new insights into the development of the relationship between anesthesia exposure and OLs, and provide a theoretical basis for clinical prevention of neurodevelopmental risks of general anesthesia drugs.
少突胶质细胞（OLs）参与髓鞘的形成，促进动作电位的传播，其增殖和分化的破坏会导致中枢神经系统（CNS）损伤。随着外科技术的进步，越来越多的儿童在生命早期接受多次手术，最近的实验表明单次或多次麻醉会对大脑发育产生影响。越来越多的临床研究表明麻醉药物对神经系统发育的影响可能主要存在于神经元之间的连接中，而髓鞘发育将受到更多的研究关注。在本文中，我们综述了麻醉暴露与大脑和少突胶质细胞之间的关系，为麻醉暴露与少突胶质细胞之间关系的发展提供新的见解，并为临床预防全身麻醉药物的神经发育风险提供理论依据。
