Huang Xin, Yao Minhao, Tian Peixin, Wong Jason Y Y, Li Zilin, Liu Zhonghua, Zhao Jie V
medRxiv. 2022 Jun 1:2022.05.21.22275413. doi: 10.1101/2022.05.21.22275413.
Venous thromboembolism (VTE) occurs in up to one third patients with COVID-19. VTE and COVID-19 may share a common genetic architecture, which has not been clarified yet. To fill this gap, we leveraged summary-level genetic data from the latest COVID-19 host genetics consortium and UK Biobank and examined the shared genetic etiology and causal relationship between COVID-19 and VTE. The cross-trait analysis identified 8, 11, and 7 shared loci between VTE and severe COVID-19, COVID-19 hospitalization, SARS-CoV-2 infection respectively, in 13 genes involved in coagulation and immune function and enriched in the lung. Co-localization analysis identified eight shared loci in and genes. Bi-direction Mendelian randomization suggested that VTE was associated with higher risks of all COVID-19 related traits, and SARS-CoV-2 infection was associated with higher risk of VTE. Our study provided timely evidence and novel insights into the genetic etiology between COVID-19 and VTE.
静脉血栓栓塞症（VTE）在多达三分之一的新冠病毒病（COVID-19）患者中出现。VTE和COVID-19可能具有尚未明确的共同遗传结构。为填补这一空白，我们利用了来自最新的COVID-19宿主遗传学联盟和英国生物银行的汇总水平遗传数据，并研究了COVID-19与VTE之间的共同遗传病因及因果关系。跨性状分析在分别与严重COVID-19、COVID-19住院治疗、严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染相关的VTE中，确定了8个、11个和7个共享基因座，这些基因座存在于13个参与凝血和免疫功能并在肺部富集的基因中。共定位分析在[具体基因]和[具体基因]中确定了8个共享基因座。双向孟德尔随机化表明，VTE与所有COVID-19相关性状的较高风险相关，而SARS-CoV-2感染与VTE的较高风险相关。我们的研究为COVID-19与VTE之间的遗传病因提供了及时的证据和新的见解。
