Mungmunpuntipantip Rujittika, Wiwanitkit Viroj
Consultant, Private Consultant, Bangkok 102002022, Thailand.
Department of Community Medicine, Dr. DY Patil University, Pune 310330, India.
World J Virol. 2022 May 25;11(3):144-149. doi: 10.5501/wjv.v11.i3.144.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants are currently a new hazard. Since the first appearance of classical SARS-CoV-2 in late 2019, pathogen genetic alterations have continued to occur, and some new hazardous forms have already emerged. The underlying pathophysiological process leading to clinical issue is molecular change caused by genetic mutation.
To determine the change in the interaction between receptor binding domain of omicron variant SARS-CoV-2 and the angiotensin-converting enzyme 2 (ACE2).
The researchers investigated how alterations in the binding area of the SARS receptor CoV2 interacted electrostatically with the ACE2 receptor. In this report, three important coronavirus disease 2019 variants, beta, delta, and omicron, were investigated.
According to this study, there was a change of electrostatic interactions between the receptor binding domain of SARS-CoV-2 with the ACE2 receptor due to each studied variant. The most change was detected in omicron variant followed by delta variant and beta variant.
Our results may support the clinical finding that the omicron variant is more transmissible than the wild type and other variants.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）变体目前是一种新的危害。自2019年末经典SARS-CoV-2首次出现以来，病原体基因改变持续发生，一些新的危险形式已经出现。导致临床问题的潜在病理生理过程是基因突变引起的分子变化。
确定奥密克戎变体SARS-CoV-2的受体结合域与血管紧张素转换酶2（ACE2）之间相互作用的变化。
研究人员研究了SARS-CoV-2受体结合区域的改变如何与ACE2受体发生静电相互作用。在本报告中，研究了三种重要的2019冠状病毒病变体，即β、δ和奥密克戎。
根据本研究，由于每个研究的变体，SARS-CoV-2的受体结合域与ACE2受体之间的静电相互作用发生了变化。在奥密克戎变体中检测到的变化最大，其次是δ变体和β变体。
我们的结果可能支持奥密克戎变体比野生型和其他变体更具传播性这一临床发现。
