Department of Biochemistry, CSIR-Central Food Technological Research Institute (CFTRI), KRS Road, Opp. Rail Museum, Mysuru 570020, India.
School of Food Science and Environmental Health, College of Sciences and Health, Technological University Dublin - City Campus, Central Quad, Grangegorman, Dublin D07 ADY7, Ireland; Environmental Sustainability and Health Institute, Technological University Dublin - City Campus, Grangegorman, Dublin D07 H6K8, Ireland.
Biomed Pharmacother. 2022 Aug;152:113148. doi: 10.1016/j.biopha.2022.113148. Epub 2022 Jun 2.
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia and insulin resistance. Gut microbiota (GM) are specific groups of microbes colonized in the gastrointestinal (GI) tract. They profoundly influence health, disease protection, and associated with metabolic activities, and play a vital role in the production of functional metabolites from dietary substances. Dysbiosis of GM has been linked to the onset of T2DM and can be altered to attain eubiosis by intervention with various nutritional bioactive compounds such as polyphenols, prebiotics, and probiotics. This review presents an overview of the evidence and underlying mechanisms by which bioactive compounds modulate the GM for the prevention and management of T2DM.
2 型糖尿病（T2DM）是一种以高血糖和胰岛素抵抗为特征的慢性代谢性疾病。肠道微生物群（GM）是定植在胃肠道（GI）中的特定微生物群。它们深刻地影响着健康、疾病保护，并与代谢活动有关，在从膳食物质中产生功能性代谢物方面发挥着重要作用。GM 的失调与 T2DM 的发生有关，可以通过干预各种营养生物活性化合物（如多酚、益生元和益生菌）来改变以达到生态平衡。本综述介绍了生物活性化合物调节 GM 以预防和管理 T2DM 的证据和潜在机制。
