Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Department of Immunopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Clin Exp Med. 2023 Jun;23(2):539-545. doi: 10.1007/s10238-022-00837-w. Epub 2022 Jun 6.
Sjogren's syndrome (SS) is a multisystem disorder of autoimmune etiology, which can be primary or secondary. Quality of life in SS depends on severity of involvement of different systems. The aims of this study are to analyze peripheral nervous system involvement in primary and secondary SS and its impact on quality of life (QOL). In this cross-sectional observational study conducted between January 2020 and June 2021, 67 patients of SS attending to this tertiary care center were included. Nerve conduction study and sympathetic skin response test were done in all cases. QOL was assessed with SF-36 questionnaire. Out of 67 cases, 50 had primary and 17 had secondary SS. 50.7% of cases had peripheral neuropathy. In primary SS, prevalence of peripheral neuropathy was 56% as against 35.3% in secondary. 50% of peripheral neuropathy were asymptomatic and were diagnosed after electrodiagnostic tests. Polyneuropathy was the most common pattern. There was no difference of other system involvement or immunological markers among those with and without peripheral neuropathy in either primary or secondary SS. Cases with peripheral neuropathy in the primary Sjogren's group and in the cohort as a whole scored significantly lower in 7 domains of SF-36. Peripheral nervous system involvement is common in Sjogren's syndrome, and most of them are asymptomatic. Peripheral neuropathy has significant impact on QOL in people with SS. Early detection and halting the progression of asymptomatic cases can be helpful in improving QOL.
干燥综合征（SS）是一种自身免疫性病因的多系统疾病，可分为原发性或继发性。SS 的生活质量取决于不同系统受累的严重程度。本研究旨在分析原发性和继发性 SS 中周围神经系统受累及其对生活质量（QOL）的影响。在这项 2020 年 1 月至 2021 年 6 月期间进行的横断面观察性研究中，纳入了 67 名在这家三级保健中心就诊的 SS 患者。所有患者均进行了神经传导研究和交感皮肤反应测试。使用 SF-36 问卷评估 QOL。在 67 例患者中，50 例为原发性 SS，17 例为继发性 SS。50.7%的患者有周围神经病。在原发性 SS 中，周围神经病的患病率为 56%，而继发性 SS 为 35.3%。50%的周围神经病为无症状，在电诊断测试后诊断。多发性神经病是最常见的类型。原发性 SS 中有无周围神经病的患者在其他系统受累或免疫标志物方面无差异。原发性干燥综合征组和整个队列中伴有周围神经病的患者在 SF-36 的 7 个领域的评分显著降低。周围神经系统受累在干燥综合征中很常见，其中大多数为无症状。周围神经病对 SS 患者的 QOL 有重大影响。早期发现和阻止无症状病例的进展有助于改善 QOL。
