Nelson Meghan Corrigan, Gibson Sinclair, Villacis-Nunez D Sofia, Kimi Chan Lai Hin, Ponder Lori, Prahalad Sampath, Moorthy L Nandini
Department of Pediatrics, 12239Emory University School of Medicine, Atlanta, GA, USA.
1367Children's Healthcare of Atlanta, Atlanta, GA, USA.
Lupus. 2022 Aug;31(9):1114-1120. doi: 10.1177/09612033221106154. Epub 2022 Jun 6.
Childhood systemic lupus erythematosus (cSLE) is a life-long disease with significant morbidity and mortality, and with associated significant impact on health-related quality of life (HRQOL). Previous literature supports that physical activity has positive impact on HRQOL in patients with chronic diseases, including cSLE. We sought to describe the physical activity of our patients with cSLE and determine the relationship between physical activity, SLE activity, treatment modalities and HRQOL in cSLE. Children ≤18 years of age with cSLE and their parents were enrolled and completed corresponding child and parent Simple Measure of Impact of Lupus Erythematosus in Youngsters reports (cSMILEY and pSMILEY, respectively), and the Physical Activity Questionnaire for Children (PAQ-C) or Adolescents (PAQ-A). Through retrospective chart review, we assessed the SLE Disease Activity Index (SLEDAI) using the SLEDAI-2K assessment tool. Descriptive statistics as well as Pearson's correlation coefficients were performed with the data obtained. Forty-four children and their parents were enrolled; clinical data, SMILEY and PAQ-C or PAQ-A scores of cSLE subjects were evaluated. The most frequently reported physical activity modality was walking (61.3%), with mean frequency of 3.7 ± 1.8 days a week, and a median of 3.5 days a week. Although there was no correlation noted between treatment modalities and PAQ-C/PAQ-A, there was weak correlation between SLEDAI and PAQ-C/PAQ-A (Pearson correlation= 0.2, ρ = 0.1, p = = 44). There was a weak correlation between SMILEY total score and PAQ [cSMILEY and PAQ-C/PAQ-A combined cohorts (Pearson correlation = 0.2, ρ = 0.3, p = = 44), and modest correlation between pSMILEY scores and PAQ-C/PAQ-A combined cohorts (Pearson correlation = 0.3, ρ = 0.3, p = = 44)] Our study emphasizes the need for larger samples to understand the prognostic value of activity levels and the extent to which increasing physical activity might be linked to improvements in HRQOL in this vulnerable population.
儿童系统性红斑狼疮（cSLE）是一种终身疾病，具有较高的发病率和死亡率，并对健康相关生活质量（HRQOL）产生重大影响。既往文献支持体育活动对包括cSLE在内的慢性病患者的HRQOL有积极影响。我们试图描述我们的cSLE患者的体育活动情况，并确定cSLE患者体育活动、SLE活动、治疗方式与HRQOL之间的关系。纳入年龄≤18岁的cSLE患儿及其父母，他们分别完成了相应的儿童和家长版狼疮对青少年影响简易量表报告（分别为cSMILEY和pSMILEY），以及儿童体育活动问卷（PAQ-C）或青少年体育活动问卷（PAQ-A）。通过回顾性病历审查，我们使用SLEDAI-2K评估工具评估SLE疾病活动指数（SLEDAI）。对获得的数据进行描述性统计以及Pearson相关系数分析。共纳入44名儿童及其父母；评估了cSLE受试者的临床数据、SMILEY以及PAQ-C或PAQ-A评分。最常报告的体育活动方式是步行（61.3%），平均频率为每周3.7±1.8天，中位数为每周3.5天。虽然未发现治疗方式与PAQ-C/PAQ-A之间存在相关性，但SLEDAI与PAQ-C/PAQ-A之间存在弱相关性（Pearson相关系数=0.2，ρ=0.1，p==44）。SMILEY总分与PAQ之间存在弱相关性[cSMILEY与PAQ-C/PAQ-A合并队列（Pearson相关系数=0.2，ρ=0.3，p==44）]，pSMILEY评分与PAQ-C/PAQ-A合并队列之间存在适度相关性（Pearson相关系数=0.3，ρ=0.3，p==44）。我们的研究强调需要更大的样本量来了解活动水平的预后价值，以及增加体育活动在多大程度上可能与改善这一弱势群体的HRQOL相关。
