INFANT Research Centre, University College Cork, Cork, Ireland; School of Public Health, University College Cork, Cork, Ireland.
INFANT Research Centre, University College Cork, Cork, Ireland; School of Public Health, University College Cork, Cork, Ireland.
Eur J Obstet Gynecol Reprod Biol. 2022 Jul;274:197-203. doi: 10.1016/j.ejogrb.2022.05.034. Epub 2022 May 31.
Examine the association between alcohol consumption before and during pregnancy and neurodevelopmental outcomes in the offspring at two and five years.
Retrospective analysis of a prospective longitudinal cohort; SCOPE-BASELINE. Data on pre-conception and prenatal alcohol consumption were obtained at 15 weeks' gestation and categorised as abstinent, occasional-low (1-7units/week) and moderate-heavy (≥8units/week). Binge drinking was defined as ≥6 units/session. Outcome measures (Child Behaviour Checklist and Kaufman Brief Intelligence Test) were obtained at two and five years. Linear regression examined an alcohol consumption and Child Behaviour Checklist and Kaufman Brief Intelligence Test relationship, adjusting for several potential confounders.
Data on alcohol consumption was available for 1,507 women. Adjusted linear regression suggested few associations: pre-pregnancy occasional-low alcohol consumption was associated with lower log externalizing Child Behaviour Checklist scores (-0.264, 95% CI: -0.009, -0.520), while pre-pregnancy moderate-high levels of alcohol consumption was associated with lower Kaufman Brief Intelligence Test verbal standard scores (-0.034, 95% CI: -0.001, -0.068) and composite IQ scores (-0.028, 95% CI: -0.056, -0.0004) at five-years. In the first trimester, moderate-high levels of alcohol consumption was associated with lower internalizing Child Behaviour Checklist scores at two-years (-0.252, 95% CI: -0.074, -0.430). No significant associations were observed between number of binge episodes pre-pregnancy or binge drinking in the first trimester and Child Behaviour Checklist or Kaufman Brief Intelligence Test.
We did not find strong evidence of associations between pre-pregnancy and early pregnancy maternal alcohol consumption and adverse neurodevelopmental outcomes at age two and five years overall. Further research examining alcohol consumption (including binge drinking) beyond 15 weeks' gestation and subsequent neurodevelopmental outcomes is needed to examine the potential effect of alcohol consumption in later pregnancy.
研究妊娠前和妊娠期间饮酒与后代两岁和五岁时神经发育结局的关系。
前瞻性纵向队列的回顾性分析；SCOPE-BASELINE。在 15 周妊娠时获得孕前和产前饮酒的数据，并分为戒酒、偶尔少量（每周 1-7 单位）和中度大量（每周≥8 单位）。狂饮定义为≥6 单位/次。在两岁和五岁时获得行为检查表和 Kaufman 简明智力测试结果。线性回归分析了饮酒与行为检查表和 Kaufman 简明智力测试结果的关系，调整了几个潜在的混杂因素。
1507 名妇女的酒精消费数据可用。调整后的线性回归表明，很少有相关性：孕前偶尔少量饮酒与外部行为检查表的对数得分较低有关（-0.264，95%CI：-0.009，-0.520），而孕前中度大量饮酒与 Kaufman 简明智力测试的言语标准得分较低有关（-0.034，95%CI：-0.001，-0.068）和复合智商得分较低（-0.028，95%CI：-0.056，-0.0004）在五岁时。在孕早期，中度大量饮酒与两岁时内部行为检查表的分数较低有关（-0.252，95%CI：-0.074，-0.430）。在孕前或孕早期狂饮次数与行为检查表或 Kaufman 简明智力测试之间未观察到显著相关性。
我们没有发现强有力的证据表明，总体而言，妊娠前和妊娠早期母亲饮酒与两岁和五岁时的不良神经发育结局之间存在关联。需要进一步研究在 15 周妊娠后和随后的神经发育结局中检查酒精消费（包括狂饮），以检查妊娠后期酒精消费的潜在影响。
