全谷物摄入与非酒精性脂肪性肝病的关系：TCLSIH 队列研究。

Relationship between the consumption of wholegrain and nonalcoholic fatty liver disease: The TCLSIH cohort study.

机构信息

Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China.

Department of Clinical Pharmacy, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.

出版信息

Clin Nutr. 2022 Jul;41(7):1483-1490. doi: 10.1016/j.clnu.2022.05.009. Epub 2022 May 18.

DOI:10.1016/j.clnu.2022.05.009

PMID:35667264

Abstract

BACKGROUND & AIMS: Wholegrain contributes a range of beneficial nutrients and is considered to play a role in the prevention of chronic diseases, but evidence of their influence on nonalcoholic fatty liver disease (NAFLD) is limited. We conducted this study to investigate the prospective association between daily wholegrain consumption and NAFLD in the general population.

METHODS

This prospective cohort study included a total of 14,968 (42.2% men) inhabitants living in Tianjin, China. Participants without a history of CVD, cancer, alcoholic fatty liver disease, other liver diseases, or NAFLD were followed up for 1-6 years with a median follow-up duration of 4.2 years. Wholegrain consumption was assessed using a validated self-administered food frequency questionnaire. NAFLD was diagnosed with the results of liver ultrasonography without significant alcohol consumption and other causes of liver disease. Cox proportional hazards regression models were used to estimate the association between wholegrain consumption and NAFLD.

RESULTS

A total of 3505 (2171 men) first incident cases of NAFLD occurred during 53,303 person-years of follow-up (median follow-up of 4.2 years). After adjusting for several potential confounders and setting "almost never" as the control group, the multivariable hazard ratios (95% confidence intervals) of the NAFLD were 0.82 (0.73, 0.92) when they consuming ≤1 time/week, 0.78 (0.69, 0.88) when they consuming 2-6 time/week and 0.77 (0.66, 0.90) when they consuming ≥1 time/day (p for trend <0.001).

CONCLUSION

The results from our prospective study demonstrated that the higher consumption of wholegrain is associated with a decreased risk of NAFLD in Chinese adults.

摘要

背景与目的

全谷物提供了一系列有益的营养物质，被认为在预防慢性病方面发挥作用，但它们对非酒精性脂肪性肝病（NAFLD）的影响证据有限。我们进行这项研究，旨在调查一般人群中全谷物日常摄入量与 NAFLD 之间的前瞻性关联。

方法

这项前瞻性队列研究共纳入了居住在中国天津的 14968 名（42.2%为男性）居民。参与者在无 CVD、癌症、酒精性脂肪肝、其他肝病或 NAFLD 病史的情况下，随访 1-6 年，中位随访时间为 4.2 年。全谷物摄入量通过经过验证的自我管理食物频率问卷进行评估。NAFLD 通过无明显酒精摄入和其他肝病病因的肝脏超声检查结果进行诊断。使用 Cox 比例风险回归模型来估计全谷物摄入量与 NAFLD 之间的关联。

结果

在 53303 人年的随访期间（中位随访时间为 4.2 年），共发生 3505 例（2171 例为男性）新发 NAFLD 病例。在调整了几个潜在的混杂因素后，将“几乎从不”作为对照组，每周食用≤1 次、每周食用 2-6 次和每天食用≥1 次的多变量危险比（95%置信区间）分别为 0.82（0.73，0.92）、0.78（0.69，0.88）和 0.77（0.66，0.90）（趋势检验 p<0.001）。