Liverpool Center for Cardiovascular Science, University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool, United Kingdom; Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom.
Liverpool Center for Cardiovascular Science, University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool, United Kingdom; Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom; Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
J Am Med Dir Assoc. 2022 Sep;23(9):1548-1554.e11. doi: 10.1016/j.jamda.2022.05.003. Epub 2022 Jun 3.
To determine the proportion of older people moving to care homes with a recent stroke, incidence of stroke after moving to a care home, mortality following stroke, and secondary stroke prevention management in older care home residents.
Retrospective cohort study using population-scale individual-level linked data sources between 2003 and 2018 in the Secure Anonymized Information Linkage (SAIL) Databank.
People aged ≥65 years residing in long-term care homes in Wales.
Competing risk models and logistic regression models were used to examine the association between prior stroke, incident stroke, and mortality following stroke.
Of 86,602 individuals, 7.0% (n = 6055) experienced a stroke in the 12 months prior to care home entry. The incidence of stroke within 12 months after entry to a care home was 26.2 per 1000 person-years [95% confidence interval (CI) 25.0, 27.5]. Previous stroke was associated with higher risk of incident stroke after moving to a care home (subdistribution hazard ratio 1.83, 95% CI 1.57, 2.13) and 30-day mortality following stroke (odds ratio 2.18, 95% CI 1.59, 2.98). Severe frailty was not significantly associated with risk of stroke or 30-day mortality following stroke. Secondary stroke prevention included statins (51.0%), antiplatelets (61.2%), anticoagulants (52.4% of those with atrial fibrillation), and antihypertensives (92.1% of those with hypertension).
At the time of care home entry, individuals with history of stroke in the previous 12 months are at a higher risk of incident stroke and mortality following an incident stroke. These individuals are frequently not prescribed medications for secondary stroke prevention. Further evidence is needed to determine the optimal care pathways for older people living in long-term care homes with history of stroke.
确定近期发生中风后搬入养老院的老年人比例、搬入养老院后中风的发生率、中风后的死亡率以及养老院中老年人的二级中风预防管理情况。
利用 2003 年至 2018 年期间 Secure Anonymized Information Linkage(SAIL)数据库中的人群规模个体水平链接数据源进行的回顾性队列研究。
居住在威尔士长期护理院的 65 岁及以上人群。
使用竞争风险模型和逻辑回归模型来检验既往中风、中风发作和中风后死亡率之间的关联。
在 86602 名个体中,7.0%(n=6055)在入住养老院前 12 个月内发生中风。入住养老院后 12 个月内中风的发生率为每 1000 人年 26.2 例[95%置信区间(CI)25.0,27.5]。既往中风与搬入养老院后中风发作的风险增加相关(亚分布风险比 1.83,95%CI 1.57,2.13)和中风后 30 天死亡率(比值比 2.18,95%CI 1.59,2.98)。严重衰弱与中风或中风后 30 天死亡率的风险无显著相关性。二级中风预防措施包括他汀类药物(51.0%)、抗血小板药物(61.2%)、抗凝剂(房颤患者中 52.4%)和降压药(高血压患者中 92.1%)。
在入住养老院时,过去 12 个月内有中风史的个体发生中风和中风后死亡率的风险较高。这些人经常没有开处方用于二级中风预防的药物。需要进一步的证据来确定有中风史的长期护理院老年人的最佳护理途径。